Janurit 50mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The medication is administered at a dose of 100 mg once daily for either monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dose adjustments for renal impairment: - Mild renal impairment (eGFR 60~90 mL/min/1.73 m2): No dose adjustment needed - Moderate renal impairment (eGFR 45~60 mL/min/1.73 m2): No dose adjustment needed - Moderate renal impairment (eGFR 30~45 mL/min/1.73 m2): 50 mg once daily. - Severe renal impairment (eGFR 15~30 mL/min/1.73 m2) or end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis (eGFR < 15 mL/min/1.73 m2): 25 mg once daily. This medication can be taken regardless of the timing of dialysis.

This medication may cause hypersensitivity reactions, so if allergic symptoms or skin rashes, dyspnea, etc. occur, discontinue use immediately and consult a doctor. ACute pancreatitis may occur, so notify medical personnel immediately if symptoms such as abdominal pain, vomiting, or loss of appetite arise. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, and it should be avoided in cases of hypersensitivity to this drug or its components. Patients with reduced renal function need dose adjustments, hence regular kidney function tests should be conducted and the medication should be taken according to the physician's instructions. This drug may induce hypoglycemia, so particularly when taken with insulin or sulfonylureas, blood sugar levels should be checked frequently and hypoglycemic symptoms need to be monitored. If severe joint pain or skin blistering symptoms occur, it is necessary to consult a doctor immediately and discontinue the medication. Pregnant or breastfeeding women are advised to avoid using this medication, and safety in pediatric and adolescent populations under 18 years of age has not been established. Elderly patients should periodically evaluate kidney function before and after taking this medication as renal function may decline. In case of overdose, visit a medical institution immediately for proper treatment, and some medications may be removed through hemodialysis. This medication has minimal interactions with other drugs, but caution is needed when used with certain medications, so inform the doctor or pharmacist of any other medications being taken.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, rash, chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe skin adverse reactions, Stevens-Johnson syndrome, acute pancreatitis, elevated liver enzymes, liver abnormalities (jaundice), acute renal failure, severe neurological symptoms, severe and debilitating joint pain, blistering dermatitis, rhabdomyolysis, severe edema accompanied by elevated blood pressure

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is recommended to be stored at room temperature between 1 and 30 degrees Celsius.

Appearance

Round, biconvex, film-coated tablet of light yellow-pink color

Package unit

30 tablets - 10 tablets/PTP[x3]