Januritine Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dosage of 100 mg for monotherapy or combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with renal impairment: 1. In cases of mild renal impairment (eGFR 60~90 mL/min/1.73 m²), no dosage adjustment is needed. 2. In cases of moderate renal impairment (eGFR 45~60 mL/min/1.73 m²), no dosage adjustment is needed. 3. Moderate

This medication may cause allergic reactions; therefore, individuals who have previously had an allergy to this medication or its components should not take it. If severe allergic symptoms such as a skin rash, difficulty breathing, or swelling of the face or neck occur during use, it should be discontinued immediately and a doctor must be consulted. There is a possibility of pancreatitis (inflammation of the pancreas) within three months after taking this medication. If symptoms such as abdominal pain, nausea, or vomiting appear, consult a doctor immediately. Patients with impaired renal function need dosage adjustments, so kidney function tests should be done and the medication should be taken under the doctor's guidance. This medication can cause hypoglycemia; therefore, when used with insulin or sulfonylurea agents, one must monitor for symptoms of hypoglycemia and may need to adjust the doses of other medications if necessary. Long-term use may result in side effects such as headache, upper respiratory infections, nasopharyngitis, joint pain, diarrhea, etc., so if symptoms are severe, consult a doctor. Elderly patients should have their renal function periodically checked before and during the use as it may decline. Pregnant or nursing women should avoid taking this medication as its safety has not been established, and it has not been confirmed for safety and efficacy in children under 18 years of age. In case of overdose, seek appropriate treatment immediately at a hospital, as some of the medication may be removed through dialysis. If any abnormal symptoms such as blisters or itching occur on the skin during the use of this medication, notify a doctor immediately, and consider stopping the medication if necessary. No significant interactions have been reported when used with other medications, but attention should be paid to the condition if digoxin is being taken.

Serious side effects

• Hives, severe swelling (angioedema), chest tightness, difficulty breathing (including anaphylaxis), cold sweat, pallor → severe allergic reaction
• Severe rash accompanied by high fever, blisters, skin peeling, mucosal pain (including Stevens-Johnson syndrome) → severe skin abnormal reaction
• Acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis) → liver abnormal reaction
• Acute renal failure → deterioration of kidney function
• Severe and

Mild side effects

• Nasopharyngitis
• upper respiratory tract infections
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air ingress, and it is best kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage will maintain the medication's effectiveness for a longer time.

Appearance

Pink, round, double-convex, film-coated tablet

Package unit

30 tablets - 10 tablets/PPP[x3]