Jakutext 500 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

For severe infections and respiratory infections in adults, take 2 tablets orally, twice a day at 12-hour intervals.

This drug is a beta-lactam antibiotic that should not be used in patients allergic to penicillin or cephalosporin drugs. Particularly, patients with viral diseases such as infectious mononucleosis or lymphocytic leukemia are at higher risk of skin rash and should avoid this medication. Patients who have had liver dysfunction or jaundice due to this drug or penicillin in the past should not use it due to the risk of recurrence. Patients with impaired liver function or severe renal impairment may have increased concentrations of this drug and should use it cautiously, with adjustments to dosing intervals as necessary. Patients with allergic tendencies or a history of symptoms such as bronchial asthma, skin rashes, or urticaria also need to use it with caution. Patients receiving parenteral nutrition, elderly individuals, or those in poor general condition may be at risk of bleeding due to vitamin K deficiency, so should be administered with caution. Patients with gastrointestinal disorders potentially resulting in vomiting or diarrhea may have impaired drug absorption, so caution is necessary. This drug may cause gastrointestinal disturbances such as diarrhea, dyspepsia, nausea, vomiting, and abdominal pain; in severe cases, it may lead to serious conditions like pseudomembranous colitis, so if symptoms are severe, it should be discontinued immediately. Regular monitoring of liver function is necessary during long-term use, as liver function tests may show abnormalities or, rarely, hepatitis and jaundice may occur. While rare, skin rashes, itching, and severe skin reactions like Stevens-Johnson syndrome can occur, so if any unusual symptoms appear, the medication should be stopped immediately and medical attention sought. Blood tests may reveal rare blood reactions such as leukopenia or thrombocytopenia, so investigations are necessary if suspicious symptoms arise. Central nervous system symptoms such as restlessness, confusion, and seizures can rarely occur, particularly in patients with impaired renal function or when given in high doses. Regular monitoring of renal function is necessary as renal deterioration or acute renal failure may occur. This drug, like other antibiotics, can alter the intestinal flora leading to conditions like candidiasis, so proper management is needed if symptoms arise. There may be a tendency for bleeding due to vitamin K deficiency; thus, patients at risk of bleeding should be cautious. Long-term administration of this drug may lead to the development of resistant strains, so it should be used for the minimum necessary duration only. Patients with a history of hypersensitivity to penicillin or multiple allergies may experience severe allergic reactions such as anaphylaxis, so this must be confirmed before administration. Post-administration, patients should be kept stable, and prompt emergency treatment is necessary in cases of anaphylactic shock. During antibiotic administration, if diarrhea or abdominal cramps occur, the possibility of pseudomembranous colitis should be considered, leading to immediate discontinuation and consultation with a physician. This drug is primarily excreted through the kidneys, so patients with decreased renal function will require dosage adjustments. It is advisable not to use this drug during the first three months of pregnancy, and pregnant or breastfeeding women should consult with a physician before use. During breastfeeding, the drug may partially transmit into breast milk, potentially causing adverse reactions such as diarrhea or rashes in infants, so caution is advised. It is not recommended for children under 12 years of age or weighing less than 40 kg. Elderly patients may be at increased risk of adverse reactions due to decreased bodily function; therefore, the dosage and interval should be carefully adjusted and monitored. This medication may affect the results of some clinical tests, so it is essential to inform healthcare providers about current medication use. In cases of overdose, symptoms such as vomiting, diarrhea, abdominal pain, drowsiness, and seizures may occur; immediate discontinuation and appropriate treatment should be sought.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions, high fever with severe rashes, blisters, peeling skin, pain in the mucous membranes of the mouth/eyes, severe skin adverse reactions, breathlessness or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice of the skin or eyes, general malaise, liver abnormalities (jaundice), sudden and severe headaches, lightning-like pain

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This drug is sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it should be kept in a cool, dry place at or below 25 degrees Celsius to maintain its efficacy.

Appearance

White or almost white rectangular film-coated tablet

Package unit

100 tablets/PTP [10 tablets/PTP x 10]