Gluliptin Duo Tablet 2.5/850 mg

Adult dose

This medication is administered twice daily with meals. The dosage should be determined considering the current treatment regimen, effectiveness, and tolerability of each patient, not exceeding the maximum recommended doses of linagliptin 2.5 mg and metformin 1000 mg for a total of 2 times a day. 1. If not previously treated with metformin: Start with an initial dose of this medication 2.5/500 mg, one tablet twice daily.

This medication is primarily used for the treatment of type 2 diabetes and helps with blood sugar control. However, it should not be administered to certain patients. For example, patients who are allergic to any components of this medication, have type 1 diabetes, lactic acidosis, diabetic ketoacidosis, diabetic coma, or who have severe renal impairment should not use it. Additionally, it should not be given in cases of acute diseases that may affect renal function such as dehydration, severe infections, acute trauma, shock, or acute myocardial infarction. Patients with reduced liver function, severe gastrointestinal disorders, acute alcohol intoxication, very poor nutritional status, or pregnant or breastfeeding women should also avoid using this medication. When using this medication, caution regarding hypoglycemic symptoms is advised, especially when taken with sulfonylureas or insulin, as there may be an increased risk of hypoglycemia necessitating dosage adjustments. Lactic acidosis, a severe side effect, can occur rarely, so if symptoms such as abdominal pain, muscle weakness, or respiratory distress occur, immediate consultation with a physician is needed. Elderly patients with compromised renal function or conditions that can alter renal function should regularly undergo renal function tests. Patients with compromised cardiac function should also periodically monitor heart and kidney status when using this medication. This medication should be temporarily discontinued before and after examinations using radiopaque iodine contrast agents, and patients scheduled for surgery should also discontinue it prior to surgery and restart it after kidney function has recovered postoperatively. Rare side effects such as pancreatitis or blistering similar to pemphigoid may occur during treatment, so if severe abdominal pain or skin abnormalities develop during use, immediate consultation with medical personnel is advised. Long-term use may lower vitamin B12 levels, thus an evaluation of vitamin B12 levels and supplementation may be necessary if anemia or neurological symptoms occur. It is recommended that women who are pregnant or planning to become pregnant avoid using this medication, and it is also advised not to use it while breastfeeding. This medication is not recommended for children under 10 years of age or adolescent patients, as safety and efficacy have not been established for this demographic. Elderly patients should periodically evaluate renal function when using this medication since renal impairment is common, and it should be administered at the minimal effective dose. In case of overdose, there is a risk of lactic acidosis, and immediate hospital treatment is necessary, possibly requiring hemodialysis. This medication should be stored away from moisture in a tightly sealed container, and it is advisable not to transfer it to other containers.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, blistering pemphigoid, angina pectoris, acute myocardial infarction, unstable angina, congestive heart failure, liver dysfunction (abnormal liver function tests, hepatitis), acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute renal failure, elevated blood pressure, severe edema, cardiac arrest, respiratory distress, asthma attacks, respiratory problems, severe allergic reactions (urticaria, severe swelling

Mild side effects

Nasopharyngitis, hypersensitivity, vitamin B12 decrease and deficiency, hypoglycemia (when combined with sulfonylureas), taste disorder, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, pruritus, erythema, rash, severe and debilitating arthralgia, rhabdomyolysis, increased lipase, increased amylase, angioedema, pruritus, rash, angioedema, urticaria, rash, angioedema

This medication should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is best kept at room temperature between 1 to 30 degrees Celsius, avoiding extremes of heat or cold.

Appearance

Biconvex oval film-coated tablet in bright orange

Package unit

60 tablets/box [(10 tablets/PTP*6)]