GluLipitin Duo Tablet 2.5/1000 mg

Adult dose

The dosage of this medication should be determined within the range of a maximum daily dose of linagliptin 2.5 mg and metformin 1000 mg, considering the patient's current therapy regimen, efficacy, and tolerability. This medication is administered 2 times a day with meals. 1. In cases not previously treated with metformin: The initial dose should be 2.5/500 mg of this medication, taken 2 times a day, with a maximum dosage of 2.5/1000 mg.

This medication is used for diabetes treatment, and one of its main ingredients, metformin, can cause rare but serious side effects such as lactic acidosis, so caution is necessary. This medication includes linagliptin and metformin, and should not be administered to certain patients. For instance, it should not be used in patients with allergies to its components or those with type 1 diabetes, lactic acidosis, diabetic ketoacidosis, severe renal impairment, liver dysfunction, acute alcohol intoxication, pregnant or breastfeeding women. Due to the risk of hypoglycemia, blood glucose levels should be carefully monitored when taken along with insulin or sulfonylurea, and dosage adjustments may be necessary. Metformin is excreted through the kidneys, so it should not be used in patients with renal impairment and renal function should be monitored regularly. Caution should be exercised in patients with poor cardiac function, acute illness, severe infection, dehydration, etc. When undergoing radiological examinations using iodinated contrast agents, this medication should be temporarily discontinued before and after the examination, and re-evaluation of renal function should be conducted before resuming. During use, acute pancreatitis or skin blistering conditions may occur, so if symptoms arise, the physician should be notified immediately. This medication may lower vitamin B12 levels, so it is important to monitor for vitamin B12 deficiency during long-term use. It is recommended not to use this medication in women who are pregnant or planning for pregnancy as well as in children under 10 years of age. Elderly patients may have impaired renal function, so dosage adjustments and regular kidney function tests are necessary. In case of overdose, there is a risk of lactic acidosis. If suspected, immediate hospital treatment is required, and blood dialysis may be beneficial. This medication should be stored out of reach of children, protected from moisture, and not transferred to other containers.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, blistering dermatoses, liver function abnormalities (abnormal liver function tests, hepatitis), severe allergic reactions (urticaria, angioedema), serious skin reactions (blistering dermatoses), acute pancreatitis, acute myocardial infarction, angina, unstable angina, cardiac arrest, congestive heart failure, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, acute pyelonephritis, sepsis

Mild side effects

Nasopharyngitis, hypersensitivity, decrease and deficiency of vitamin B12, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, abnormal liver function tests, hepatitis, pruritus, erythema, rash, oral ulceration, increased lipase, increased amylase, hypoglycemia (when combined with sulfonylurea), increased blood triglycerides, decreased hemoglobin, increased potassium in blood, increased ALT, increased AST, itching, insomnia, depression

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius. This way, the medication’s effectiveness can be preserved for a long time.

Appearance

Bright pink, biconvex, oval film-coated tablet

Package unit

60 tablets/box[(10 tablets/PTP*6)]