Gladitin Tablets (Rafutidine)

Adult dose

1. Short-term treatment of gastric ulcers The usual dose is 10mg of lafutidine orally twice daily, in the morning and before bedtime. In clinical trials with treatment for up to 8 weeks, most ulcers healed within 8 weeks, although healing time may vary occasionally among patients. 2. Short-term treatment of duodenal ulcers The usual dose is 10mg of lafutidine orally twice daily, in the morning and before bedtime. In clinical trials with treatment for up to 6 weeks, most ulcers healed within 6 weeks, although healing time may vary occasionally among patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis The usual dose is 10mg of lafutidine orally once daily before bedtime. In clinical trials with treatment for up to 2 weeks, most lesions healed within 2 weeks, although healing time may vary occasionally among patients. 4. Concomitant antibiotic therapy in patients with peptic ulcers infected with Helicobacter pylori Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication for anesthesia The usual dose is 10mg of lafutidine per dose, administered orally twice (before bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis Administer 10mg of lafutidine per dose orally twice daily.

This medication should not be used in patients with hypersensitivity to its ingredients. It also contains lactose, so patients with genetic issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should avoid it. Patients with a history of drug hypersensitivity, liver or kidney dysfunction, patients undergoing dialysis, and elderly individuals should use this medication with caution. While taking this medication, severe symptoms such as allergic reactions or anaphylaxis may occur. If symptoms like pale face, low blood pressure, and difficulty breathing appear, discontinue the medication immediately and seek medical attention. Liver dysfunction or jaundice symptoms may arise, so liver function tests should be checked regularly; if abnormalities are found, the medication should be discontinued. Initial symptoms of agranulocytosis or thrombocytopenia such as sore throat, general malaise, and fever may occur, so consult a healthcare provider immediately if these symptoms arise. Serious side effects such as seizures, skin rash, or heart problems may occur infrequently; seek immediate medical assistance if these symptoms occur. Gastrointestinal symptoms may include constipation, diarrhea, nausea, vomiting, abdominal distension, and loss of appetite. Central nervous system effects can include headache, insomnia, drowsiness, and dizziness. Blood tests may show an increase or decrease in white blood cell count, anemia, or elevated liver enzyme levels; regular testing is necessary. Elderly patients may have decreased physical function; therefore, drug dosage and administration intervals should be adjusted, and their condition should be closely monitored. Dialysis patients may have increased blood concentrations of the drug; therefore, it should be started at a low dose and taken cautiously. Pregnant women or those who may become pregnant should decide whether to take this drug based on medical advice, and breastfeeding women should avoid it as it may be secreted in breast milk. Safety in pediatric patients has not been sufficiently confirmed, so it should be avoided in children. Keep the medication out of reach of children and store it in the original container; transferring it to another container poses a risk of misuse or degradation of quality. This medication may relieve symptoms of malignant tumors or delay diagnosis; thus, if gastric ulcers are present or suspected, malignant tumor status should be confirmed, and the medication should be discontinued if diagnosed with malignant gastric cancer. During treatment, closely monitor the patient's condition and administer the minimum effective dose. If no improvement is seen, alternative treatments should be considered.

• Shock
• symptoms of anaphylaxis
• facial pallor
• hypotension
• generalized urticaria
• dyspnea
• liver dysfunction
• jaundice
• agranulocytosis
• pharyngitis

This medication should be stored in a tightly closed container to protect it from air and moisture. The recommended storage temperature is room temperature between 1 degree and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle