Losatec Plus F Tablets

Adult dose

Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily, 1 tablet. If blood pressure is not controlled, it may be increased to a maximum of Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg once daily, 1 tablet. For patients with renal impairment, the standard dose is given when creatinine clearance is 30 mL/min or more. Use of this medication is not recommended for patients with liver impairment.

Child dose

Since there is no experience with use in children and adolescents (under 18 years of age), the combination drug is not administered.

This medication can cause serious harm to the fetus if taken during pregnancy, especially in the second and third trimesters, so it must be discontinued immediately upon confirmation of pregnancy. It is safe not to administer this medication to patients with certain diseases or conditions. For example, patients with severely impaired kidney function, severe liver dysfunction, and those with certain allergy histories should not use this medication. Patients with very low blood pressure or reduced blood volume, patients with renal artery problems, and patients with liver diseases should exercise special caution when using this medication. During treatment, blood pressure, kidney function, and electrolyte levels should be regularly monitored, particularly any fluctuations in potassium levels. Due to the hydrochlorothiazide component, electrolyte imbalance, increased blood sugar, and elevated uric acid levels may occur, so any symptoms should be discussed with a physician. This medication has a strong effect on lowering blood pressure, which may lead to dizziness or drowsiness, especially shortly after starting treatment, so caution is needed when driving or operating machinery. Interactions may occur when taken with other medications, so especially when combined with potassium supplements, blood pressure medications, diuretics, or non-steroidal anti-inflammatory drugs, consultation with a physician is necessary. This medication is not recommended for use in children and adolescents, and older individuals may experience side effects slightly more frequently, necessitating caution. In case of overdose, symptoms such as low blood pressure and cardiac function abnormalities may occur, thus requiring immediate medical attention for appropriate treatment. During treatment, if there are plans for pregnancy or if pregnancy is suspected, consultation with a physician is essential. If breastfeeding, it is recommended to either stop breastfeeding or discontinue the medication. This medication may cause sensitivity to sunlight, increasing the risk of skin cancer; therefore, limiting sun exposure and frequently checking skin condition is important. Finally, this medication should be stored in its original container, out of the reach of children, and it is safest not to change the container arbitrarily.

Serious side effects

Craniosynostosis, anuria, hypotension, renal failure, death, angioedema (swelling of lips and eyelids and facial rash), skin exfoliation, hemolysis, palpitations, angina, arrhythmia, cerebrovascular accident, myocardial infarction, secondary atrioventricular block, angioedema (laryngeal/glottic swelling that can cause airway obstruction, swelling of face/lips/pharynx/tongue), vasculitis, anaphylaxis, aplastic anemia, agranulocytosis, leukopenia, hemolysis

Mild side effects

• Abdominal pain
• edema/swelling
• palpitations
• back pain
• dizziness
• cough
• sinusitis
• upper respiratory infection
• weakness/fatigue
• diarrhea

This medication is sensitive to light, so it should be stored in a container that blocks light. Additionally, it is best to keep the medication at room temperature, which should not be too cold or too hot, ideally between 1 degree to 30 degrees Celsius.

Appearance

Pale yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle