Serafen Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks at 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day if needed. From the second day onward, the recommended dose as needed is 200 mg per dose twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be discussed with a doctor or pharmacist if you regularly consume more than three glasses of alcohol a day. Taking it with alcohol can increase the risk of stomach bleeding. Due to an increased risk of heart or vascular-related diseases, patients with a history of cardiovascular disease or risk factors should be particularly cautious. It should be used for the minimum effective dose and shortest duration possible, and consult a physician if any cardiovascular symptoms appear. Serious gastrointestinal issues such as ulcers, bleeding, and perforation may occur, so individuals with a history of gastrointestinal disease should use this medication cautiously. Elderly patients and those at high risk for gastrointestinal diseases require greater caution, and seek immediate medical attention if they experience symptoms like epigastric pain, indigestion, black stools, or vomiting blood. Do not take this medicine if you have had allergic reactions to it or have had hypersensitivity to sulfonamides, aspirin, or other non-steroidal anti-inflammatory drugs. Patients with severely impaired liver or kidney function, active peptic ulcers, inflammatory bowel diseases, heart failure, ischemic heart disease, etc., should not take this medication. Patients with mild liver or kidney function, asthma, hypertension, edema, or a history of heart failure should be particularly cautious when taking this medication. Furthermore, this medication should not be administered to pregnant or breastfeeding women, and women planning to become pregnant should use it cautiously. Dizziness or drowsiness may occur during treatment, so avoid driving or operating machinery. This medication can interact with various drugs, so inform your healthcare provider about any medications you are currently taking, especially if taking other medications metabolized by the liver, as dosage adjustments may be necessary. Pregnant or breastfeeding women should avoid this medication, and if pregnancy is confirmed, discontinue use immediately. Additionally, this medication may affect female reproductive ability, so women undergoing infertility investigations or those planning to become pregnant should exercise caution. Elderly patients may have diminished kidney, liver, and heart function, thus requiring more careful monitoring when taking this medication. For long-term use of this medication, regular blood tests and liver and kidney function tests should be conducted, and report any abnormal symptoms to your healthcare provider immediately. In case of overdose, symptoms such as nausea, vomiting, drowsiness, and lethargy may occur, and in severe cases, renal failure or respiratory depression may develop, requiring immediate emergency care. Keep this medication out of reach of children, and it is safest not to transfer it to another container.

Gastrointestinal bleeding, cardiovascular thrombotic reaction, myocardial infarction, stroke, upper and lower gastrointestinal perforation, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, abdominal distension, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequency of urination, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased blood creatinine, increased β2-microglobulin, increased NAG, positive hematuria, positive proteinuria, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, chest pain, anaphylactic reaction, hallucination, cerebral hemorrhage, aseptic meningitis, loss of smell, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, female infertility, headache, dizziness, constipation, anemia, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, hyperlipidemia, diabetes, weight gain, fracture, arthralgia, RA factor positive, herpes zoster, pneumonia, respiratory distress, elevated ALT, hearing loss, lethargy, fluid retention, generalized edema, facial edema, fatigue, malaise, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, vasculitis, angioedema, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, vasculitis, contact dermatitis, injection site reaction, skin nodules, auditory loss, ear abnormalities, otalgia, hearing loss, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased sodium in blood, increased potassium in blood, increased BUN, increased CPK, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, anorexia, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendinitis, myositis, leg cramps, fracture, tendon rupture, pain in the back, muscle stiffness, decreased hematocrit, increased hemoglobin, epistaxis, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia

This medication should be stored in a closed container to prevent air and moisture from entering. Avoid storing in locations that are too hot or too cold, and it is best to maintain a temperature between 15 and 30 degrees Celsius.

Appearance

White capsules filled with powder that is white to pale yellow

Package unit

30 capsules/bottle, 100 capsules/bottle