Famotidine Tablet (Famotidine)

Adult dose

1. Gastric and duodenal ulcers, anastomotic ulcers, upper gastrointestinal bleeding, gastroesophageal reflux disease, Zollinger-Ellison syndrome: For adult patients, 20 mg orally 2 times a day (after breakfast and after dinner or at bedtime) or 40 mg orally 1 time a day (at bedtime). In cases of upper gastrointestinal bleeding, treatment generally begins with injections and is switched to oral once feasible. 2. For improvement of gastric mucosal lesions (acute gastritis, acute exacerbation of chronic gastritis)

This medication should not be used by patients who have previously shown allergic reactions to its ingredients or other H2 receptor antagonists. Additionally, this medication contains lactose; hence, it should not be administered to patients with genetic issues such as lactose intolerance, lactose deficiency, or glucose-galactose malabsorption. Patients with hypersensitivity, reduced kidney function, heart diseases, liver dysfunction, and elderly patients should use this medication with caution. In particular, patients with reduced kidney function may have increased serum concentration of the drug; therefore, dosage should be reduced or dosing intervals extended. During treatment with this medication, serious allergic reactions, blood disorders, severe skin and mucosal diseases, liver dysfunction, muscle damage, cardiac arrhythmias, consciousness disorders, nephritis, and pneumonia may occur, so careful monitoring is necessary. If any of these symptoms appear, the medication should be immediately discontinued, and appropriate treatment sought. Common side effects may include rash, urticaria, changes in blood cell counts, gastrointestinal symptoms, blood pressure changes, respiratory issues, liver function abnormalities, neuropsychiatric symptoms, endocrine disturbances, and arthralgia; if such symptoms occur, the medication should be discontinued. During treatment, the patient's condition should be closely monitored, and the medication should be used at the minimum effective dose, with a switch to other therapies recommended if ineffectiveness is noted. This medication dissolves in the mouth but is not absorbed through the oral mucosa, so it should be swallowed with saliva or water. Also, patients undergoing hemodialysis should be cautious if taking this medication with phosphate binders, as it may reduce the effectiveness of calcium carbonate. This medication may interact with certain antifungal agents or some anticancer drugs, reducing its efficacy; therefore, consultation with a doctor or pharmacist is advised when taken with other medications. Elderly patients may have reduced kidney function, resulting in increased serum drug concentration, so caution is necessary with a dosage reduction or extended dosing intervals. Pregnant women should only use this medication when the benefits outweigh the risks, as its safety has not been adequately established, and it is recommended that breastfeeding women discontinue breastfeeding as this medication may pass into breast milk. For pediatrics, caution is needed as the safety of this medication has not been established.

Serious side effects

Shock, hypersensitivity (anaphylaxis, respiratory distress, generalized flushing, angioedema, urticaria), pancytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, thrombocytopenia, Stevens-Johnson syndrome, Lyell's syndrome, liver function impairment, jaundice, rhabdomyolysis, QT prolongation, ventricular tachycardia, ventricular fibrillation, consciousness disturbance, seizures, interstitial nephritis, acute kidney failure, interstitial pneumonia, cardiac failure

Mild side effects

• Rash
• pruritus
• urticaria (erythema)
• facial swelling
• leukopenia
• eosinophilia
• constipation
• diarrhea
• light-colored stools
• dry mouth

This medication should be stored in a tightly sealed container to prevent air ingress, and it’s best to keep it at a temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle