Pioran 15 mg (Pioglitazone Hydrochloride)

Adult dose

This medicine is taken orally once a day regardless of meals. 1. Monotherapy This medicine may be started at 15 mg once a day for patients whose blood sugar is not adequately controlled with diet and exercise. If sufficient efficacy is not achieved, the dose may be increased to 30 mg once a day. 2. Combination Therapy - When used with sulfonylurea agents, the initial dose is 15 mg once a day.

Child dose

Use in children under 18 years is not recommended due to lack of experience.

This medicine may cause or worsen congestive heart failure in some patients; therefore, symptoms of heart failure such as sudden weight gain, shortness of breath, and edema should be carefully monitored after starting treatment or increasing the dose. It is advisable not to use this medicine in patients with heart failure, and if heart failure symptoms develop, should be managed according to standard treatment practices, and if needed, the administration of this medicine should be stopped or the dose reduced. When used in conjunction with other diabetes medications like insulin, fluid retention may exacerbate heart failure, so regular checks for heart failure symptoms are necessary. Additionally, this medicine carries a higher risk of heart failure in patients with a history of cardiovascular disease and should be used cautiously in elderly patients over 75 years of age. If symptoms such as hematuria, urinary disturbances, or urgency occur during treatment, it may suggest a possibility of bladder cancer, and the physician should be notified immediately. This medicine should not be administered to those with hypersensitivity, heart failure, current or past bladder cancer, liver impairment, severe renal impairment, diabetic ketoacidosis, Type 1 diabetes, or pregnant women. Caution is required for patients taking other oral hypoglycemics, premenopausal women, patients with edema, those with heart disease or renal impairment, those with poor nutritional status or excessive alcohol consumption, and elderly patients. Common side effects may include edema, weight gain, headache, upper respiratory tract infection, myalgia, pharyngitis, abdominal bloating, hypoglycemia, urinary tract infection, back pain, dizziness, diarrhea, elevated serum creatine kinase, hypertension, chest pain, fatigue, dyspepsia, nausea, itching, chest discomfort, tremors, chills, gastrointestinal disease, epigastric discomfort, numbness, rigidity, headache discomfort, increased liver enzymes, worsening liver disease, dermatitis, arthralgia, knee abnormalities, weakness in arms. In cases of overdose, appropriate treatment should be received based on symptoms, and this medicine should be kept out of reach of children and stored in its original container.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (excessive and rapid weight change, shortness of breath, edema), severe edema (including peripheral edema, generalized edema, pitting edema, and fluid retention), urticaria, liver abnormalities (abnormal liver function test values, fatigue, loss of appetite, discomfort in the right upper abdomen, dark urine, jaundice), severe allergic reaction, bladder cancer, stroke, myocardial infarction, confusion, seizures, serious neurological symptoms, severe fever.

Mild side effects

• Upper respiratory tract infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medicine should be stored in a container that protects from light and air, avoiding humid places. The storage temperature should be between 15 to 30 degrees Celsius, with around 25 degrees being ideal.

Appearance

This medicine is a white, round tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle