New Artija (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, administer 25 mg weekly for 5 consecutive weeks into the intra-articular space of the knee or shoulder (shoulder joint space, subacromial bursa, or biceps tendon sheath), but the number of administrations may be adjusted according to symptoms. This drug is administered intra-articularly and must be performed under strict aseptic procedures.

This medication should not be administered to certain patients. First, patients who have had allergic reactions to this drug or its components should not use it. Additionally, this drug should not be administered to patients with skin diseases or infections in the joints. Patients with liver dysfunction or a history of liver disease should use this medication with caution, as liver enzyme levels may become abnormal. Those with allergies to bird proteins should also avoid this drug. Severe shock reactions may occur when using this medication, so it is important to monitor the patient's condition after administration. If symptoms of an allergic reaction such as facial swelling, redness, rash, hives, or itching occur, stop use immediately and seek appropriate treatment. Transient pain, swelling, redness, warmth, severe pressure, or bruising may occur at the injection site. Additionally, symptoms such as nausea, vomiting, fever, or headache may appear. In cases of severe inflammation in the joint due to osteoarthritis, it is advisable to reduce inflammation before using this drug. After administration, it is necessary to stabilize the joint area and avoid excessive exercise. Care should be taken to prevent the medication from leaking outside the joint, and patients with rheumatoid arthritis or gout may experience temporary worsening of inflammation. Intense activities or prolonged weight-bearing exercises such as jogging or tennis should be avoided within 48 hours post-administration. Using this medication together with other intra-articular injectables is not recommended as safety and efficacy have not been confirmed. Pregnant women or those who may become pregnant should carefully use this drug only when the benefits outweigh the risks, as its safety has not been established. Also, since this drug may be excreted in breast milk, it is advisable to avoid use during breastfeeding. When administering this drug to children, it should only be used cautiously when absolutely necessary, as its safety has not been sufficiently confirmed. Elderly patients should be especially cautious when using this drug due to potential decline in physical functions. This medication is administered as an intra-articular injection and must be given under aseptic conditions accurately. If symptoms do not improve, administration should be stopped within 5 uses. If there is excessive joint fluid, it is advisable to remove it before injection. Intravascular administration is prohibited, and it is not to be used for ophthalmic purposes. When injecting, use an appropriately sized needle, shake the ampoule to ensure uniformity of content and then slowly aspirate into the syringe. When cutting the ampoule, it should be disinfected beforehand to avoid contamination. Care should be taken, as this medication does not mix with disinfectants like benzalkonium chloride or chlorhexidine. This drug is for single use, so it should be used immediately after opening, and any remaining portion should be discarded. It is recommended to administer a local anesthetic prior to using this drug.

Serious side effects

Hives

Mild side effects

Swelling (facial, eyelid, etc.), facial flushing, rarely rash, itching, pain (mostly transient pain post-administration), swelling, rarely edema, redness, warmth, localized severe pressure, petechiae, nausea, vomiting, fever, headache

This medication should be stored in a sealed container to prevent exposure to air or moisture, ideally at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer time.

Appearance

A colorless, transparent viscous liquid filled in a glass vial sealed at both ends with rubber stoppers (part of a prefilled syringe system)

Package unit

10 prefilled syringes/box [2.5 milliliters/prefilled syringe]