Piglene Tablets (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily regardless of meals. For monotherapy, start with 15 mg once daily; if the effect is insufficient, it may be increased to 30 mg once daily. In combined therapy, 15 mg is administered once daily with sulfonylureas, metformin, or insulin. The maximum recommended dosage does not exceed 30 mg once daily.

Child dose

There is no experience with use in children under 18 years, so administration is not recommended.

This medication may cause or exacerbate congestive heart failure in some patients. Therefore, symptoms of heart failure, such as sudden weight gain or difficulty breathing, should be carefully monitored during treatment with this medication. If such symptoms occur, it is essential to consult a doctor immediately to receive appropriate treatment, and if necessary, to discontinue or reduce the dose of the medication. Patients with heart failure should not use this medication, and it is not recommended for patients with symptoms of heart failure. This medication may cause fluid retention and edema when taken with insulin, and the appearance of such symptoms should be carefully observed. Additionally, patients with bladder cancer or a history of bladder cancer should not take this medication, and they should inform their doctor immediately if visible hematuria or urinary disturbances occur. This medication should also not be administered to patients with severely impaired liver function, severe kidney impairment, type 1 diabetes, or diabetic ketoacidosis. Women who are pregnant or may become pregnant must consult a doctor before taking this medication. This medication carries a risk of hypoglycemia, so when taken with insulin or other antidiabetic agents, hypoglycemic symptoms should be closely monitored, and dosages of other medications adjusted if necessary. Edema or weight gain may occur; if these symptoms appear, a consultation with a doctor is advisable, particularly for patients with heart disease. If symptoms of liver dysfunction arise, immediate medical attention should be sought, and routine liver function tests are recommended. Regular monitoring of blood sugar and liver function is necessary while taking this medication, and any abnormal symptoms should promptly be reported to a doctor. Moreover, premenopausal women should use an appropriate contraceptive method, as this medication may induce ovulation. Elderly patients or those with renal or hepatic dysfunction should use this medication with caution, and may require dosage adjustments or regular check-ups. The safety and efficacy of this medication in children have not been established, thus it is not recommended for use in this population. In cases of overdose, appropriate treatment should be provided according to symptoms, and a physician's guidance should be followed. Lastly, this medication should be kept out of reach of children and stored in its original container.

Serious side effects

Congestive heart failure, edema, heart failure, severe swelling, difficulty breathing, severe allergic reactions, hives, cold sweat, pallor, chest tightness, liver abnormalities (jaundice), liver failure, significant heart failure, stroke, myocardial infarction, stroke, hypertension, heart irregularities, bladder cancer, confusion, visual disturbances, paralysis, seizures, severe headaches, asthma attacks, respiratory abnormalities accompanied by fever, severe skin reactions, severe rashes, blisters.

Mild side effects

• Upper respiratory tract infections
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infections
• back pain

This medication should be stored in a container that protects it from light and air, avoiding humid areas. The appropriate storage temperature is between 15 degrees and 30 degrees Celsius, ideally around room temperature of 25 degrees.

Appearance

White round tablets

Package unit

30 tablets/bottle, 300 tablets/bottle