AtorvaTablets 20mg (Atorvastatin Calcium Trihydrate)

Adult dosage

Start with 10mg once daily, and if a greater reduction in LDL cholesterol is needed, it can be initiated at 20mg or 40mg once daily. Generally, the dosage is adjusted within the range of 10mg to 80mg once daily. Personalized adjustments should be made based on treatment goals and patient responses, with lipid levels analyzed every 2 to 4 weeks to inform dosage adjustments. For patients with homozygous familial hypercholesterolemia, the dosing is 10mg to 80mg once daily, administered either alongside other lipid-lowering treatments (e.g., LDL apheresis) or when such treatments are not possible. For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the recommended initial dose is 10mg once daily, with a maximum recommended dose of 20mg daily (there is no clinical data for doses higher than 20mg in this pediatric population). Doses should be adjusted appropriately based on individual patients' therapeutic goals, with adjustments every 4 weeks or longer if necessary. For patients with renal impairment: Renal disease does not affect atorvastatin plasma concentrations or LDL cholesterol reduction effects, so dose adjustments are not necessary. For elderly patients: The efficacy and safety in patients over 70 years of age are generally similar to those in the adult patient population.

Children's dosage

For pediatric patients aged 10 to 17 with heterozygous familial hypercholesterolemia, the recommended initial dose is 10mg once daily, with a maximum dose of 20mg once daily. Dosage adjustments should be made individually based on therapeutic goals every 4 weeks.

This medication may cause muscle-related symptoms, thus it should be discontinued immediately if muscle pain or weakness worsens or creatine kinase levels rise significantly. Patients with liver function problems or active liver diseases should not take this medication. It should not be administered to women with muscle disorders, those who are pregnant or breastfeeding, and children under 10 years of age. Alcoholics or patients with a history of liver disease should use this medication with caution, particularly elderly patients or those with impaired kidney function should also be monitored carefully. While taking this medication, regular liver function tests and muscle-related tests should be conducted, and if abnormal symptoms appear, consult a physician immediately. Drug interactions may occur when taken with other medications, especially with certain antibiotics, antifungals, antivirals, and grapefruit juice, so attention is needed during co-administration. Appropriate contraceptive methods should be used while taking this medication, and if pregnancy is confirmed, it should be discontinued. This medication can rarely cause serious skin rashes or allergic reactions, so it should be stopped immediately if skin abnormalities occur. There is no specific antidote in case of overdose, so appropriate treatment should be received based on symptoms, and liver function and muscle condition should be monitored through blood tests. It should be stored out of reach of children and kept in its original container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, mucosal pain in the mouth/eyes, yellowing of the skin or eyes (jaundice), extreme tiredness all over, sudden and severe headache, lightning headache, seizures, confusion, vision disturbances, paralysis, significantly reduced urine output, severe swelling of the body with elevated blood pressure, anaphylaxis

Mild side effects

• Fatigue
• malaise
• chest pain
• peripheral edema
• tiredness
• fever
• rhinitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. This helps to preserve the drug's efficacy and safety over time.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle