Inizentaduo Tablet 2.5/850 mg

Adult dose

The dosage of this medication should be determined considering the current therapy, efficacy, and tolerability of each patient, while not exceeding the maximum recommended doses of linagliptin 2.5 mg and metformin 1000 mg, administered twice daily. This medication should be taken twice daily with meals. 1. If the patient is not currently receiving treatment with metformin: Start with an initial dose of this medication 2.5/500 mg, to be taken twice daily, with one tablet per dose.

This medication can cause a rare side effect known as lactic acidosis, which is serious and can lead to death if treatment is delayed. It should not be used in certain patients, for example, those with allergies to its components, type 1 diabetes, lactic acidosis, diabetic ketoacidosis, or severe renal impairment. Patients with compromised renal function, acute infections, dehydration, severe trauma, shock, or acute myocardial infarction—conditions that may affect renal function—should use this medication with caution. It is not recommended for use in pregnant women or those who may become pregnant, as well as nursing mothers. When used with other blood glucose-lowering medications, there is an increased risk of hypoglycemia, so careful monitoring of blood sugar levels is necessary. To reduce the risk of lactic acidosis, renal function should be regularly checked and this medication temporarily stopped in situations that could cause dehydration or acute renal damage. If symptoms such as muscle cramps, abdominal pain, or severe fatigue occur during the use of this medication, it is important to inform a doctor immediately. This medication may reduce vitamin B12 levels, so it is necessary to periodically check vitamin B12 concentrations in the blood during long-term use. In addition, this medication may interact with some drugs, so it is essential to consult a doctor or pharmacist if taking other medications. If iodine-containing contrast agents are used for surgery or radiologic examinations, this medication should be discontinued for a certain period before and after the examination and resumed only after renal function is restored. Elderly patients are prone to renal function decline, so renal function should be frequently checked, and dosage adjustments may be needed when taking this medication. During the treatment, if blistering skin diseases or severe joint pain occurs, consult a physician immediately. Finally, this medication is not recommended for use in children or children under 10 years of age.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory problems accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and very severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Hypoglycemia, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, pruritus, erythema, rash, musculoskeletal and connective tissue disorders, increased lipase, increased amylase, decreased and deficiency of vitamin B12, dyspepsia, stomatitis, dizziness, drowsiness, chest pain, fever, itching, insomnia, depression, hypertension, lightheadedness, erectile dysfunction, goiter,

This medication is sensitive to air and moisture, so it must be stored in a tightly closed container. The storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature. Storing it this way will help maintain its effectiveness for a long time.

Appearance

Bright orange, biconvex, oval film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP×6]