Glarinduol Tablet 2.5/1000 Milligrams

Adult dose

This medication should be taken twice daily with meals. The dosage should not exceed the maximum recommended doses of Linagliptin 2.5 mg and Metformin 1000 mg, considering the patient's current treatment regimen, effectiveness, and tolerability. 1. If not previously treated with Metformin: - Initial dosage: This drug 2.5/500 mg, 1 tablet twice daily - Upon increasing dosage: this drug 2

This medication may cause a serious side effect called lactic acidosis, so caution is required. It should not be used in patients with allergies to any of the components of this drug or in those with type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. It should not be administered to patients with severely impaired kidney function or in situations where acute changes in kidney function may occur. Furthermore, patients with severe heart disease or liver dysfunction, acute alcohol intoxication, or very poor nutritional status should avoid using this drug. Pregnant or breastfeeding women are also advised not to use this medication. As this drug can cause hypoglycemia, it is essential to monitor blood sugar levels closely, especially when taken with insulin or sulfonylurea. To reduce the risk of lactic acidosis, regular kidney function tests are necessary; this medication should be temporarily discontinued during acute illnesses such as dehydration, severe infections, or trauma. If acute pancreatitis or skin blistering is experienced, immediate consultation with a doctor is required. This medication can lower vitamin B12 levels, therefore checking for vitamin B12 deficiency is necessary during long-term use. When used in conjunction with other drugs, interactions may occur, so it is important to inform the doctor or pharmacist and take caution. For those planning to become pregnant or who are pregnant, insulin therapy is recommended for blood sugar control instead of this drug. Safety in children under 10 years old and adolescents is not established, so it is preferable not to administer it. In elderly patients, there may be a decline in kidney function; hence, dosage adjustments and regular kidney function tests are necessary. In cases of overdose, lactic acidosis may occur and immediate medical attention should be sought; hemodialysis is an effective treatment method. This medication should be kept out of reach of children and stored away from moisture.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, blistering dermatosis, liver abnormalities (hepatitis, abnormal liver function tests), angina pectoris, acute myocardial infarction, unstable angina, cardiac arrest, acute kidney injury, end-stage kidney disease, pneumonia, shortness of breath, asthma, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rash with fever, blisters)

Mild side effects

• Nasopharyngitis
• hypersensitivity
• decreased vitamin B12 and deficiency
• hypoglycemia
• dysgeusia
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. The recommended storage temperature is between 1 and 30 degrees Celsius.

Appearance

Bright pink, biconvex, oval film-coated tablet

Package unit

60 tablets/box [(10 tablets/PTP packaging x 6)]