Diseren M Capsule (Diacerein)

Adult dose

Adults: Administer 50–100 mg of diacerein per day orally in 1–2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50 mg once daily for the first 2–4 weeks is recommended, followed by 50 mg twice daily.

This medication should not be administered to patients with certain conditions. For example, patients with inflammatory bowel disease, those with intestinal obstruction, or patients with unexplained abdominal pain should not use this drug. Additionally, patients who are allergic to this drug or its components, as well as those with liver disease or a history of liver disease, should also avoid it. It is not for use in children under 15 years of age. This medication contains lactose, so it should not be given to patients with genetic disorders that affect lactose digestion. Patients with a history of small intestine or colon diseases should use this drug cautiously, and pregnant or breastfeeding women should also exercise caution when administering it. Elderly patients aged 65 and older should reduce the dosage accordingly. This medication may affect the gastrointestinal system, leading to diarrhea, loose stools, and abdominal pain. Long-term use may result in serious issues such as gastrointestinal bleeding, ulcers, or perforations; therefore, caution is required. Severe diarrhea may lead to dehydration or electrolyte imbalance, so if such symptoms occur, discontinue use immediately and consult a physician. Skin reactions such as itching, rashes, and eczema may occur frequently, and although liver dysfunction is rare, it is advisable to regularly check liver health. When taking this medication for an extended period, it is crucial to follow a doctor's instructions, and concomitant use with other laxatives should be avoided. This medication may interfere with absorption when taken with antacids containing calcium, magnesium, or aluminum, or with salt, so it should be taken at least two hours apart. Furthermore, concomitant use with diuretics may result in excessive diuretic effects, increasing the risk of dehydration and hypokalemia, so caution is needed. When taken with cardiac glycosides, the risk of arrhythmias may increase, so consult with a physician. Pregnant or breastfeeding women should ideally avoid using this medication due to potential effects on the fetus or infant. In cases of overdose, severe diarrhea may occur, necessitating appropriate treatment, such as electrolyte replenishment.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevation of liver enzymes in serum

This medication must be stored in a tightly closed container to prevent exposure to air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

A hard capsule filled with a yellowish-brown content, white at the (top) and yellow at the (bottom).

Package unit

30 capsules/bottle, 500 capsules/bottle