Linagliptin Metformin Duo Tablet 2.5/850 mg

Adult dose

This drug is administered twice daily with meals. To reduce gastrointestinal side effects associated with metformin use, dosage increases should proceed gradually. 1. In case of not being treated with metformin currently: The initial dose of this drug 2.5/500 mg is 1 tablet twice daily, and it can be increased up to 1 tablet twice daily of the 2.5/1000 mg formulation. 2. When blood glucose control is inadequate with metformin monotherapy:

This drug helps control blood glucose levels. However, during treatment, there is a risk of serious adverse effects such as lactic acidosis, which requires caution. Lactic acidosis occurs when there is an excessive buildup of lactic acid in the body, and if untreated, it can be life-threatening. This drug should not be administered to certain patients. For example, those who are allergic to any ingredient in this drug, patients with Type 1 diabetes, severe renal impairment, acute myocardial infarction, heart failure, liver dysfunction, acute alcohol intoxication or alcoholism, pregnant women, or breastfeeding mothers should not take this drug. There is a risk of hypoglycemia, so blood glucose levels should be closely monitored, especially when taking medications such as insulin or sulfonylureas. Immediate action is necessary if hypoglycemic symptoms occur. Patients with impaired renal function should undergo renal function tests before taking this drug and regularly monitor renal function during treatment. If renal function declines severely, this drug should be discontinued. Patients with weak heart function need to be cautious while taking this drug and periodically check cardiac and renal function. If a patient receives iodinated contrast agents used in radiological examinations, this drug should be temporarily discontinued before and after the examination, and resumed only after renal function has stabilized. Patients scheduled for surgery should stop taking this drug 48 hours before surgery and can resume after renal function has recovered post-surgery. Acute pancreatitis or bullous skin diseases may occur during treatment, so if persistent and severe abdominal pain or skin abnormalities occur, consult a doctor immediately. The metformin component can lower vitamin B12 levels, so checking for vitamin B12 deficiency regularly during long-term use is advisable. This drug may interact with other medications, so it is essential to inform your physician or pharmacist about any other medications being taken, especially when using drugs that affect renal function. It is advisable for pregnant women or those planning to become pregnant to avoid taking this drug and to refrain from use while breastfeeding. Safety and efficacy have not been sufficiently established for children under 10 years and adolescents aged 10 to 17 years, so use is not recommended. Elderly patients are likely to have reduced kidney function, so renal function should be evaluated and monitored regularly before starting this drug. In cases of overdose, there is a risk of lactic acidosis, and if suspected, medical attention should be sought immediately. This drug should be stored in a sealed container to avoid exposure to air or moisture, and stored at room temperature between 1 to 30 degrees Celsius to maintain its effectiveness.

Serious side effects

Hives, angioedema, lactic acidosis, chest tightness, breathlessness, acute pancreatitis, bullous pemphigoid, abnormal liver function (including abnormal liver function tests, hepatitis, fatty liver), angina, acute myocardial infarction, unstable angina, cardiac arrest, heart failure with edema, seizures, confusion, visual disturbances, paralysis, severe allergic reactions, severe skin reactions, respiratory issues, liver dysfunction (jaundice), severe

Mild side effects

• Nasopharyngitis
• hypersensitivity
• decreased and deficiency of vitamin B12
• hypoglycemia
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This drug is sensitive to air and moisture and must be kept in a sealed container. Additionally, it is important to store it at room temperature between 1 and 30 degrees Celsius to maintain its effectiveness.

Appearance

Bright orange oval-shaped film-coated tablets with a double convex surface

Package unit

60 tablets/box [(10 tablets/PTP x 6)]