Izifru Tablet 1 mg (Prucalopride Succinate)

Adult dose

This medication is taken orally and can be administered at any time during the day regardless of meals. Adults take 2 mg once daily. For elderly patients aged 65 and over, the initial dose is 1 mg once daily, which may be increased to 2 mg once daily if necessary. For patients with severe renal impairment (GFR < 30 ml/min/1.73 m2) and severe liver impairment (Child-Pugh class C), the dosage is 1 daily.

This medication should not be administered to certain patients. Specifically, those allergic to the active ingredient or any additives, patients with severely impaired kidney function requiring dialysis, and individuals with serious structural abnormalities or inflammation in the intestines should not use it. Additionally, those with lactose intolerance or certain genetic metabolic disorders should not take this medication. Use with caution and a reduced dosage for patients with poor kidney function. Patients with severe issues relating to the liver, heart, lungs, or nervous system also require caution when using this medication. Individuals with heart rhythm issues or a history of ischemic heart disease should also be careful, and the dosage may need to be lowered for patients with severely diminished liver function. This medication can commonly cause gastrointestinal symptoms such as headaches, abdominal pain, nausea, and diarrhea, which usually resolve within a few days of starting treatment. Dizziness, fatigue, and palpitations may also occur, and if unusual symptoms persist, consultation with a physician is advised. In cases of severe diarrhea, the effectiveness of oral contraceptives may decrease, so it is advisable to use additional contraceptive methods. This medication has a low risk of interactions with other drugs, but caution is needed when taken with certain potent medications. Particularly when combined with medications that can prolong the QTc interval, there may be a risk of side effects, and consultation with a physician is necessary. Use of this medication during pregnancy is not recommended, and women of childbearing potential should employ effective contraception during treatment. It is also not recommended for breastfeeding women. It is advisable not to administer this medication to children or adolescents under 18 years of age. In case of overdose, symptoms such as headaches, nausea, and diarrhea may occur, and appropriate treatment must be provided according to the symptoms. Particularly, dehydration and electrolyte imbalance may occur, so caution is necessary. Dizziness or fatigue may occur while driving or operating machinery, so caution is needed. This medication should be stored out of reach of children and kept in its original container away from moisture.

Serious side effects

Ventricular extrasystole, chest discomfort

Mild side effects

• Headache
• dizziness
• tremor
• palpitations
• nausea
• diarrhea
• abdominal pain
• vomiting
• dyspepsia
• rectal bleeding

This medication should be stored in a sealed container that does not allow light exposure, avoiding humid areas, at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication’s effectiveness and prevents degradation.

Appearance

White to off-white round film-coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu*2)