Ariphe Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. The dose of 5 mg should be administered for 4 to 6 weeks. After assessing clinical response, the dose may be increased to 10 mg. When increasing to 10 mg per day, attention should be paid to gastrointestinal adverse reactions during administration.

Child dose

No experience in pediatric use.

This medication contains Donepezil Hydrochloride Hydrate as the main ingredient and is used to treat symptoms of Alzheimer's type dementia. This medication should not be used in certain patients. For example, patients allergic to this medication or its components, women who are pregnant or may become pregnant, and women who are breastfeeding should not take this medication. Additionally, patients with lactose intolerance or genetic disorders affecting lactose metabolism should also refrain from taking this medication. Patients with heart disease, a history of peptic ulcers, a history of asthma or obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease should take this medication with caution. Particularly, patients allergic to yellow No. 5 dye contained in this medication should be cautious. While taking this medication, various adverse reactions may occur. Heart-related issues may include bradycardia, heart block, and myocardial infarction, while gastrointestinal issues may include nausea, vomiting, diarrhea, and gastrointestinal bleeding. Additionally, severe adverse reactions such as liver dysfunction, seizures, extrapyramidal symptoms, shortness of breath, acute pancreatitis, and acute renal failure may occur, so it is important to consult a healthcare professional immediately if any unusual symptoms arise. This medication, as an acetylcholinesterase inhibitor, can affect heart rate, potentially causing bradycardia or arrhythmias, so patients with heart disease should be particularly cautious and may require ECG monitoring. Moreover, this medication increases gastric acid secretion and promotes gastrointestinal motility, posing a risk of exacerbating peptic ulcers; therefore, patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should carefully monitor their condition. This medication acts on the brain and nervous system, potentially worsening extrapyramidal symptoms similar to those seen in Parkinson's disease, and respiratory symptoms may worsen in patients with asthma or obstructive lung disease, so caution is advised. Women who are pregnant or breastfeeding are generally advised not to take this medication, and if unavoidable, must consult a physician before use. This medication may interact with several other drugs. Particularly, caution is advisable when taken with drugs that affect CYP3A4 and CYP2D6 enzymes, as the efficacy may change. Also, when combined with drugs affecting cardiac conduction, there may be increased risk of arrhythmias requiring ECG monitoring. This medication may impair the ability to drive or operate machinery, so caution is recommended when starting or increasing the dosage. In case of overdose, symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, respiratory suppression, and seizures may occur, which requires immediate medical attention. This medication should be kept out of reach of children, and transferring it to other containers may compromise its quality.

Serious side effects

Urticaria, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in the mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary retention

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• hallucinations
• agitation

This medication should be stored in a tightly sealed container to prevent air exposure and at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle