Donepezil 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Donepezil hydrochloride is administered at a dose of 5 mg once daily before bedtime. Use 5 mg for 4-6 weeks, evaluating clinical response before increasing to 10 mg. When increasing to a daily dose of 10 mg, it is necessary to monitor for gastrointestinal adverse reactions. Underweight female patients over 85 years should not exceed 5 mg daily and require careful monitoring.

Child dose

There is no experience with pediatric use.

This medication should not be used in patients who are allergic to its components, pregnant or breastfeeding women. Patients with lactose intolerance or certain genetic conditions should not take this medication. Patients with heart disease or irregular heartbeats should use this medication cautiously as it may cause heart rhythm issues. Patients with a history of peptic ulcers or who are taking anti-inflammatory painkillers should exercise caution due to the possibility of gastrointestinal bleeding or exacerbation of ulcers while using this medication. Patients with asthma or a history of obstructive lung disease should be cautious as this medication may worsen respiratory symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should use this medication carefully as it may exacerbate symptoms. During the use of this medication, severe side effects such as fainting, heart issues, gastrointestinal bleeding, liver dysfunction, seizures, and muscular abnormalities may occur; any unusual symptoms should be reported to medical personnel immediately. Patients with dementia may frequently experience gastrointestinal symptoms such as nausea, vomiting, diarrhea, and loss of appetite, which are mostly mild and temporary. This medication can affect heart rhythm, so regular ECG examinations may be necessary for patients with heart diseases or a history of QT interval prolongation. It may affect driving or machinery operation, so caution is needed during the initial dosage or when the dosage is changed. There may be interactions with other medications, especially when used concurrently with heart medications, antibiotics, antidepressants, or antipsychotic drugs; consultation with a specialist is required. Pregnant or breastfeeding women should avoid this medication unless it is indispensable, in which case consulting a specialist is recommended. Safety in children has not been confirmed, so it should not be used in children. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, and respiratory depression may manifest, necessitating immediate medical attention, and antidotes may be used if necessary. This medication should be stored out of the reach of children and should not be transferred to other containers.

Serious side effects

• Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor
• → Severe allergic reaction
• High fever accompanied by severe rash, blisters, peeling skin, pain in the mouth/eye mucosa
• → Severe skin reaction
• Shortness of breath or difficulty breathing, asthma attacks, cough and fever accompanying respiratory issues
• → Respiratory problems
• Skin or eyes turning yellow (jaundice), extreme lethargy
• → Liver issues (jaundice)
• Acute

Mild side effects

• Nausea
• vomiting
• dizziness
• diarrhea
• insomnia
• abdominal pain
• loss of appetite
• headache
• fatigue
• drowsiness

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, it should be stored at room temperature between 1°C and 30°C for safety.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle