Rinatru Duo Tablet 2.5/500 mg

Adult dose

The dosage of this medication is determined by considering each ingredient's maximum recommended dose of linagliptin 2.5 mg and metformin 1000 mg not to exceed 2 times a day, while taking into account each patient's current treatment regimen, efficacy, and tolerance. This medication is administered 2 times a day with meals. 1. If currently not being treated with metformin: Initial dose of this medication is 2.5/500 mg taken 1 tablet 2 times a day.

This medication can cause a serious side effect known as lactic acidosis, so it should not be used in patients with impaired kidney function or liver problems. Patients allergic to any component of this medication or those with severe diseases such as type 1 diabetes, diabetic ketoacidosis, heart failure, or acute myocardial infarction should also not take it. This medication is not recommended for use in pregnant or breastfeeding women, and should be avoided if pregnancy is planned. When used in combination with other diabetic medications that lower blood sugar, there is an increased risk of hypoglycemia, so caution is necessary, especially when combined with insulin or sulfonylureas, as dosage adjustment may be required. Elderly patients with impaired kidney function should have their renal function regularly monitored while using this medication, and the dosage should be adjusted as needed. When receiving iodine-based contrast agents used for radiological examinations, this medication should be discontinued for a certain period before and after the examination, and resumption should occur after renal function stabilizes. This medication may cause side effects such as gastrointestinal disturbances, abdominal pain, diarrhea, and vomiting; if symptoms are severe, consult a doctor. Additionally, rare side effects like acute pancreatitis or bullous pemphigoid may occur, so if persistent and severe abdominal pain or skin abnormalities occur, stop taking the medication immediately and inform healthcare personnel. Long-term use may lead to vitamin B12 deficiency, so if there are signs of anemia or neurological symptoms, vitamin B12 levels should be checked and supplementation should be provided if necessary. It is advisable to avoid alcohol intake during the use of this medication, especially in cases of acute alcohol intoxication. Before undergoing surgery, this medication should be discontinued at least 48 hours prior, and should be resumed only after confirming the normalization of kidney function post-surgery. Safety and efficacy have not been established in children and adolescents, so it is not recommended for use in this population. This medication should be kept out of the reach of children and stored away from moisture.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function tests, hepatitis, acute pancreatitis, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, severe allergic reactions, skin adverse reactions, respiratory problems, liver abnormalities (jaundice), severe neurological symptoms (headache, seizures, consciousness confusion, vision abnormalities, paralysis), severe edema or urination abnormalities, angina, acute myocardial infarction, unstable angina, cardiac arrest

Mild side effects

• Nasopharyngitis
• hypersensitivity
• vitamin B12 reduction and deficiency
• taste disorders
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication should be stored in a tightly sealed container to protect it from air and moisture. To maintain the effectiveness of the drug, it is important to keep it at a cool room temperature, specifically between 1 and 30 degrees Celsius.

Appearance

Bright yellow oval film-coated tablet

Package unit

60 tablets/box [(10 tablets/PTP × 6)]