Glotin Duo Tablet 2.5/850 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is taken twice a day with meals. 1. If not currently being treated with metformin: Take this medication 2.5/500 mg twice daily, 1 tablet each time, and can increase to 1 tablet of this medication 2.5/1000 mg twice daily. 2. If sufficient blood sugar control cannot be achieved with metformin monotherapy: Take 2.5 mg of linagliptin twice daily and the existing dose of metformin.

This medication can cause a serious side effect known as lactic acidosis; therefore, patients with poor kidney function or issues with heart or liver function should not take it. Additionally, individuals allergic to any of its components, those with type 1 diabetes, acute myocardial infarction, in shock, or pregnant or breastfeeding women should not take this medication. Caution is necessary when used with other diabetes medications or insulin that have a risk of hypoglycemia; if symptoms of hypoglycemia occur, immediate consultation with medical personnel is required. Elderly patients with reduced kidney function or those taking medications that may affect kidney function should regularly undergo kidney function tests while taking this medication. This medication should temporarily be discontinued before and after iodine contrast administration during acute infections, dehydration, or surgical procedures, and can be resumed once kidney function is stabilized. Use of this medication should be done cautiously in patients with liver dysfunction or severe gastrointestinal disorders, and it should be avoided in patients with acute alcohol intoxication or alcoholism. During treatment, attention should be given to the possible occurrence of rare skin disorders such as pancreatitis or bullous pemphigoid, and if symptoms appear, the physician should be notified immediately. Furthermore, this medication may decrease vitamin B12 levels; thus, it is important to regularly check for vitamin B12 deficiency if taken over a long period. Use of this medication is not recommended for women planning to become pregnant, those who are pregnant, or children under 10 years of age. Elderly patients should start with the minimum dose considering reduced kidney function and regular monitoring of kidney function is needed. The impact on driving or operating machinery is not known, so caution is advised. In case of overdose, there is a risk of lactic acidosis; immediate hospital visit for treatment is necessary, and blood dialysis may be required. This medication should be stored out of reach of children, kept away from moisture, and not transferred to another container.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function (hepatitis, abnormal liver function tests), severe edema, acute pancreatitis, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, angina pectoris, acute myocardial infarction, unstable angina, cardiac arrest, severe allergic reactions, severe rash with high fever, blisters, skin peeling, oral/eye mucosal pain, shortness of breath or difficulty breathing, asthma attack

Mild side effects

Nasopharyngitis, various immune system disorders, decreased vitamin B12, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, pruritus, erythema, rash, oral ulcer formation, abnormal liver function tests, hepatitis, severe joint pain accompanied by disability, rhabdomyolysis, increased lipase, increased amylase, hypoglycemia, decreased and deficiency of vitamin B12, increased serum triglycerides, elevated ALT, elevated AST,

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. Additionally, it is important to store it at room temperature between 1 and 30 degrees Celsius to maintain its efficacy.

Appearance

Bright orange, convex, oval-shaped film-coated tablets

Package unit

30 tablets/box [(6 tablets/PTP x 5 packs)]