Megasimvastatin Tablets (Simvastatin)

Adult dose

1. The recommended initial starting dosage for the reduction of cardiovascular disease risk is 40 mg once daily. 2. For the treatment of hyperlipidemia, the typical initial starting dosage is 20 mg administered once daily in the evening. Patients with mild to moderate hypercholesterolemia may start with 10 mg, adjusting the dosage to 5 to 40 mg taken once daily in the evening. The dosage should be adjusted based on LDL cholesterol levels and treatment objectives.

Child dose

The recommended initial dosage for pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17) is 10 mg once daily in the evening, with a recommended dosage range of 10 to 40 mg per day and a maximum dosage of 40 mg per day.

This medication is used to lower blood cholesterol levels. Caution is needed as muscle-related side effects such as muscle pain or weakness may occur during use. Particularly, if taken at high doses or in combination with other specific medications, the risk of muscle damage may increase. Patients with liver disease or abnormal liver function test results should not take this medication as it can affect liver function. Women who are pregnant or may become pregnant and breastfeeding women should not take this medication. This medication may interact with certain antifungal drugs, antibiotics, and immunosuppressants, increasing the risk of muscle damage when taken together, so consultation with a physician is necessary. Special attention is required for the elderly, patients with impaired kidney function, and those with hypothyroidism. If unexplained muscle pain, tenderness, or weakness occurs during use, patients should inform their doctors immediately, and if symptoms are severe, they should discontinue the medication. Symptoms indicating liver function abnormalities or allergic reactions should also prompt immediate consultation with healthcare professionals. This medication is not recommended for children under 10 years old, and adolescents aged 10 and older should take it under the guidance of a physician. It is advisable to avoid taking this medication with certain foods such as grapefruit juice. This medication must be taken strictly according to a physician's prescription and instructions, and patients should inform other physicians about taking this medication when receiving treatment.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor, high fever, severe rash, blisters, peeling skin, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output

Mild side effects

• Abdominal pain
• weakness
• constipation
• diarrhea
• indigestion
• bloating
• nausea
• headache
• upper respiratory infection
• abdominal pain

This medication should be stored in a tightly closed container to avoid exposure to air and moisture, and it is best kept at temperatures between 1 degree to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Brownish-yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle