J-Pezil Tablet 5mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After 4 to 6 weeks, evaluate clinical response, and may increase up to 10 mg. When increasing to 10 mg per day, administer with caution regarding gastrointestinal adverse reactions. Underweight female patients aged over 85 should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience in using this drug for children.

This medication contains Donepezil Hydrochloride Monohydrate as its main ingredient and is used to alleviate symptoms of Alzheimer's-type dementia. This drug should not be administered to certain patients. For example, individuals with allergies to this drug or its components, pregnant women or those who may become pregnant, nursing mothers, and those with genetic lactose intolerance should not take this medication. Patients with heart disease or conduction disorders, those with a history of peptic ulcers or taking non-steroidal anti-inflammatory drugs, asthmatic patients or those with obstructive pulmonary disease, patients with extrapyramidal disorders such as Parkinson's disease, and those allergic to the yellow No. 5 dye contained in this drug should take it with caution. Various adverse reactions may occur while taking this medication. For example, heart-related problems (bradycardia, heart block, myocardial infarction, etc.), gastrointestinal issues (peptic ulcers, gastrointestinal bleeding, etc.), hepatic dysfunction, neurological abnormalities (seizures, intracerebral hemorrhage, etc.), motor dysfunction, dyspnea, acute pancreatitis, acute renal failure have been reported. In addition, common side effects such as nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, headache, fatigue, rash may occur, and these symptoms are usually mild and temporary. This medication is approved for use only in patients with Alzheimer's-type dementia and should not be used for other forms of dementia or memory disorders. Treatment should be conducted under the supervision of an experienced physician, with regular evaluation of the patient's condition and consideration for discontinuation if there is no effect. It may affect the cardiovascular system, so patients with heart disease or a history of QT interval prolongation may require an ECG. Additionally, patients with gastrointestinal diseases should closely monitor for worsening symptoms. This drug may affect driving or operating machinery, so caution is needed during initial use or when dosage changes occur. Pregnant or nursing women should avoid using this medication, and if necessary, consult a specialist. This medicine can interact with several drugs; therefore, if you are taking other medications, you must inform your healthcare provider. In particular, caution is required when combined with drugs that affect cardiac conduction or those that influence CYP3A4, CYP2D6 enzymes. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, respiratory repression may occur, so you should visit a medical institution immediately, and an antidote such as atropine may be used. Lastly, this medication should be kept out of reach of children, and transferring it to another container should be avoided as it may lead to a decline in quality or accidents.

Serious side effects

Syncope, bradycardia, heart block, heart failure, myocardial infarction, peptic ulcer, perforation of the duodenum, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures, intracerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders, neuroleptic malignant syndrome, rhabdomyolysis, dyspnea, acute pancreatitis, acute renal failure, unexplained sudden death, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, etc.).

Mild side effects

Nausea, vomiting, diarrhea, loss of appetite, headache, fatigue, drowsiness, dizziness, insomnia, aggressive behavior, hallucinations, anxiety, delusions, depression, confusion, sleepiness, muscle pain, rash, itching, fever, decreased body temperature, thrombocytopenia, urinary incontinence, frequent urination, urinary disorders, edema, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, blood pressure fluctuations (increase/decrease), palpitations, atrial fibrillation, sinus bradycardia.

This medicine should be stored in a tightly sealed container to prevent air or moisture exposure, and it is best kept at a temperature between 1°C and 30°C at room temperature. By following this storage guideline, the effectiveness of the drug can be maintained and degradation prevented.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle