Mega Hyaluron Plus Injection (Sodium Hyaluronate)

Adult dosage

Generally, for adults, administer 1 vial once a week for 3 consecutive weeks into the knee joint or shoulder joint, but the frequency of administration may be adjusted according to symptoms.

This drug contains sodium hyaluronate, which is administered via injection into the joint. It should not be used in patients who have had an allergic reaction to any of the components of this drug. Caution should be exercised when using in patients with a history of allergies to other medications, liver dysfunction, or skin diseases or infections at the injection site. After administration, severe allergic reactions or shock may occur rarely, so careful monitoring is necessary. If allergic symptoms such as swelling, redness, rash, or itching occur around the face or eyes, use should be discontinued immediately and appropriate treatment should be sought. Temporary symptoms such as pain, swelling, warmth, or pressure in the injected joint area may occur. Symptoms like nausea, vomiting, or fever may also arise, so any unusual symptoms should be reported. In joints with severe inflammation, this drug may worsen symptoms, so it is advisable to resolve inflammation before use. After injection, the joint area must be stabilized, and care should be taken to prevent leakage of the drug outside the joint. Injections should be performed strictly inside the joint under sterile conditions, and if there is no effect, it should be discontinued after three administrations. If there is a large amount of joint fluid, aspiration may be necessary before injecting. This drug should not be directly injected into blood vessels or the eyes, and a needle size of 22-23 gauge is appropriate. Caution should be taken as certain disinfectants may cause precipitates when mixed with this drug. Women who are pregnant or may become pregnant should use this drug cautiously, as its safety is not assured unless absolutely necessary. Additionally, if breastfeeding, it is advisable to avoid using this drug as it may be transmitted in breast milk. Safety in children has not been established, so it should only be used cautiously when necessary. Elderly patients may exhibit decreased physical function, so care should be taken in use.

Serious side effects

Shock symptoms (severe allergic reactions).

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial flushing
• rash
• itching
• pain (transient post-injection)
• enlargement
• edema
• redness
• warmth
• local pressure sensation

This drug should be stored in a sealed container to prevent air from entering, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness over a longer period.

Appearance

A clear, colorless viscous solution filled in a colorless and transparent glass vial sealed with rubber stoppers at both ends (part of a pre-filled syringe system).

Package unit

2mL x 1 vial, 2mL x 3 vials