Medication info

Rasat Tablet 0.5 mg (Rasagiline Mesylate)

Prescription medicationTabletOralApproval withdrawn
Ingredient · strength
Rasagiline Mesylate›0.78mg / 1 tablet
Manufacturer / importer
Korea Prime Pharmaceutical Co., Ltd.
Appearance
White round tablet
Packaging
30 tablets/box [(10 tablets/PTP X 3)]
Approval status
Approval withdrawn

MFDS item code 202000008 · Approved 2020.01.02

This product's status changed to Approval withdrawn on 2024.09.19. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Treatment of idiopathic Parkinson’s disease
Who takes it
Adults
Adult dose
This drug is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1 mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended initial dose for patients taking levodopa is 0.5 mg once daily. If well tolerated and the clinical response is insufficient, the dose may be increased to 1 mg once daily. This drug may be taken with or without food.

Ingredients

Manufacturer
Korea Prime Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of idiopathic Parkinson’s disease

  • Idiopathic Parkinson's disease
  • motor fluctuations
View approved original text

This medication is used in the treatment of idiopathic Parkinson's disease. Initially, it is used alone or in combination with a dopamine agonist to alleviate symptoms. Additionally, when motor fluctuations occur during levodopa treatment, it is administered as an adjunct therapy to help control symptoms. This improves the motor function and quality of life of patients.

How to take

Adult dose

This drug is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1 mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended initial dose for patients taking levodopa is 0.5 mg once daily. If well tolerated and the clinical response is insufficient, the dose may be increased to 1 mg once daily. This drug may be taken with or without food.

Precautions

This medication should not be used by patients who are allergic to the active ingredient or other components. Additionally, it should not be administered to patients who are taking other MAO inhibitors, certain analgesics, cough medications, or those who have stopped such medication within the last 2 weeks. It is also not safe to use this medication in patients with moderate to severe liver function impairment. During treatment, various side effects such as flu-like symptoms, skin cancer, leukopenia, allergies, appetite reduction, depression, hallucinations, headaches, conjunctivitis, dizziness, angina, rhinitis, dermatitis, musculoskeletal pain, urinary urgency, fever, and fatigue may occur; hence, caution is advised. In particular, when taken with levodopa, movement disorders or low blood pressure may occur, and consultation with a healthcare provider is necessary. This medication can cause drowsiness or sudden sleep, so caution must be exercised when driving or operating machinery, and it can be dangerous when taken with sedatives or alcohol. Additionally, symptoms of impulse control disorders, such as compulsive behavior or pathological gambling, may appear during treatment, so both patients and caregivers should closely monitor for changes. If pregnant or breastfeeding, it is crucial to consult with a healthcare provider regarding the use of this medication, and careful consideration should be given to dosing or use in children and the elderly. In cases of overdose, severe symptoms may occur, and immediate medical attention should be sought. This medication has many interactions with other medications; thus, inform healthcare professionals about any other medications being taken. Finally, keep this medication out of the reach of children, and store it in a suitable environment to maintain its quality.

Side effects

  • influenza
  • skin cancer
  • leukopenia
  • allergy
  • loss of appetite
  • depression
  • hallucinations
  • headache
  • cerebrovascular accident
  • conjunctivitis
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  • dizziness
  • angina
  • myocardial infarction
  • rhinitis
  • bloating
  • dermatitis
  • vesicular rash
  • musculoskeletal pain
  • cervical pain
  • arthritis
  • urgency
  • fever
  • malaise
  • peripheral edema
  • falls
  • arthralgia
  • cough
  • insomnia
  • upper respiratory infection
  • orthostatic hypotension
  • nausea
  • constipation
  • vomiting
  • dry mouth
  • diarrhea
  • abdominal pain
  • indigestion
  • hernia
  • infection
  • gingivitis
  • accidental injury
  • weight loss
  • tendinitis
  • movement disorders
  • drowsiness
  • sensory disturbances
  • ataxia
  • muscle tension abnormalities
  • myasthenia
  • anorexia
  • abnormal dreams
  • respiratory distress
  • rash
  • hyperhidrosis
  • bleeding spots
  • bleeding
  • melanoma
  • confusion
  • carpal tunnel syndrome
  • balance disorders
  • hypertension
  • pathological gambling
  • increased libido
  • hypersexuality
  • compulsive spending or purchasing
  • binge eating
  • compulsive eating
  • hypotension
  • excessive drowsiness
  • acute renal failure
  • spinal fracture
  • rib fracture
  • tendon injury
  • pelvic fracture
  • leg fracture
  • upper limb fracture
  • back pain
  • knee arthroplasty
  • herniated disc
  • hypoglycemia
  • weight loss
  • urinary difficulty
  • malignant hyperthermia
  • generalized weakness
  • pulmonary tuberculosis
  • hallucinations
  • semicoma
  • gait disturbances
  • oculomotor seizures
  • facial paralysis
  • spinal canal stenosis
  • exacerbation of Parkinson's disease
  • subdural hemorrhage
  • pneumonia
  • myalgia
  • osteoporosis
  • limb weakness
  • concussion
  • unspecified abrasion
  • laceration
  • scoliosis
  • thirst
  • hematuria
  • frequent urination
  • vaginitis
  • conjunctival injection
  • diplopia
  • visual impairment
  • skin thickening
  • palpitations
  • arrhythmia
  • gastrointestinal discomfort
  • gas reflux
  • excessive salivation
  • irritable bowel syndrome
  • fissured tongue
  • increased bowel frequency
  • unspecified gastrointestinal disease
  • esophagitis
  • excessive gastric acid
  • gastroesophageal reflux
  • gastric irritation
  • gastritis
  • intestinal motility disorders
  • periodontitis
  • Helicobacter pylori gastritis
  • anemia
  • leg pain
  • chest pain
  • syncope
  • periorbital edema
  • facial flushing
  • fever
  • pain
  • delusion
  • sleep disorders
  • aggression
  • amnesia
  • memory impairment
  • lethargy
  • sleep talking
  • psychosexual disorder
  • skin tingling
  • tremor
  • freezing phenomenon
  • limb shaking
  • myoclonic jerks
  • leg cramps
  • polyuria
  • tremor
  • stuttering
  • vocal dysfunction
  • language impairment
  • localized inflammation
  • itching
  • urticaria
  • eyelid skin disease
  • furuncle
  • hair loss
  • contusion
  • sputum abnormalities
  • increased sputum
  • cold
  • bronchitis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to protect it from air or moisture. It is crucial to keep it in a cool place, between 1 to 25 degrees Celsius, to maintain its effectiveness.

Appearance and packaging

Appearance

White round tablet

Package unit

30 tablets/box [(10 tablets/PTP X 3)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.