Donepezil Tablets 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As donepezil hydrochloride, typically administer 5 mg once daily in the evening. If disturbances in sleep occur, such as unusual dreams, nightmares, or insomnia, consider morning dosing. Administer the 5 mg dose for 4 to 6 weeks, then assess clinical response before increasing to 10 mg as needed. When increasing to 10 mg daily, monitor for gastrointestinal adverse effects. Underweight female patients aged 85 years and older should not exceed 5 mg daily.

Child dose

There is no experience of use in children.

This drug is used to alleviate symptoms of Alzheimer's type dementia, with donepezil hydrochloride as the main ingredient. First, this medication should not be administered to patients who are allergic to donepezil hydrochloride or piperidine derivatives, or to any other components of this medicine. It is also advisable that women who are pregnant or may become pregnant, as well as breastfeeding women, do not use this medication. Additionally, since it contains lactose, patients with genetic disorders such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine. Patients with cardiac diseases, particularly those with syncope syndrome or conduction disturbances, should be careful as this medication can slow heart rate or cause arrhythmias. Patients who are taking non-steroidal anti-inflammatory drugs or have a history of peptic ulcers should use this medication cautiously due to increased gastric acid secretion which may worsen ulcers. Patients with a history of asthma or obstructive lung disease may experience exacerbation of symptoms due to bronchoconstriction and increased mucus secretion, thus caution is required. In patients with extrapyramidal disorders such as Parkinson's disease, it should be administered with caution as it may worsen symptoms. Serious adverse effects such as syncope, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebral hemorrhage, cerebral seizures, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death may occur during the use of this medication; if any abnormal symptoms occur, consultation with medical personnel should be sought immediately. Commonly, mild or transient side effects such as nausea, vomiting, diarrhea, dizziness, insomnia, loss of appetite, headache, muscle pain, and rash may occur. This medication can affect cardiac conduction, hence ECG monitoring is necessary when taken together with other medications that may cause QT interval prolongation or ventricular tachycardia. Pregnant or breastfeeding women are advised to abstain from this medication, and if its use is necessary, consultation with professionals is required. This medication can affect driving or machine operation abilities; therefore, caution is needed during initial usage or when changing dosage. In case of overdose, symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, and respiratory depression may occur, and appropriate medical treatment should be sought immediately. This medication comes in sublingual form, so the correct method of administration should be followed carefully. For child safety, this medication should be stored out of reach of children and should be kept unopened to prevent discoloration by light.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in oral/eye mucous membranes, shortness of breath or breathing difficulties, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, lightning-like headaches, seizures, altered consciousness, visual disturbances, paralysis.

Mild side effects

Loss of appetite, nausea, vomiting, diarrhea, dizziness, insomnia, drowsiness, headache, fatigue, fever, increased or decreased blood pressure, palpitations, muscle pain, rash, itching, incontinence, urinary disturbances, edema, anxiety, confusion, hallucinations, aggressive behavior, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, dehydration, weight loss, thrombocytopenia, anemia, etc. are mild or common adverse reactions.

This medicine should be stored in a tightly sealed container to avoid air or moisture, at a temperature between 1 to 30 degrees Celsius (room temperature). By storing it this way, the medicine's efficacy can be well preserved.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle