Traglim Duo Tablet 2.5/500 milligrams

Adult dose

This medication is administered twice daily with meals. To minimize gastrointestinal side effects associated with metformin, dosage increases should be gradual. 1. In cases where metformin has not been used: The initial dose is 2.5/500 mg taken twice daily, one tablet per dose, and can be increased to 2.5/1000 mg taken twice daily, one tablet per dose. 2. In switching from a combination therapy of linagliptin and metformin:

This medication may cause a serious side effect known as lactic acidosis, so caution is required. Lactic acidosis is a rare but fatal metabolic complication that poses a risk, particularly to patients with poor kidney function or heart disease. It should not be administered to individuals allergic to its active ingredients or excipients, patients with Type 1 diabetes, those with severe renal impairment, or patients in acute infection or dehydration states. Pregnant or breastfeeding women should also avoid using this medication. There is a risk of hypoglycemia; therefore, blood sugar needs to be carefully monitored when used together with insulin or sulfonylureas. Patients with impaired kidney function require regular monitoring of kidney function before and during the use of this medication. This medication should be discontinued before and after procedures using iodine-based contrast agents that can cause acute kidney injury. It is also safe to stop using this medication for a period before and after surgery. This medication may lead to pancreatitis and bullous pemphigoid; hence, if continuous severe abdominal pain or blistering skin occurs, immediate consultation with a doctor is necessary. Long-term use can lead to vitamin B12 deficiency, so checking blood levels of vitamin B12 is advisable. The efficacy of this medication may change when taken with other drugs, so all medications being taken should be disclosed to healthcare providers. Elderly patients are at a common risk of reduced kidney function, making dose adjustments and monitoring renal function important. In case of overdose, the risk of lactic acidosis is increased, necessitating immediate treatment at a hospital, and blood dialysis may be required. This medication should be kept out of reach of children and stored in a place that avoids moisture.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• acute pancreatitis
• bullous pemphigoid
• abnormal liver function
• hepatitis
• angina pectoris
• acute myocardial infarction
• unstable angina

Mild side effects

• Pharyngitis
• hypersensitivity
• vitamin B12 reduction
• taste disturbance
• cough
• appetite loss
• diarrhea
• constipation
• nausea
• vomiting

This medication should be stored in a tightly sealed container that protects it from air and moisture. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius, avoiding areas with high moisture.

Appearance

Bright yellow, oval, biconvex film-coated tablets

Package unit

60 tablets/PTP - 60 tablets/PTP [(10 tablets/PTP packaging x 6 packs)]