Donepezil Tablets 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Donepezil Hydrochloride is taken as 5 mg once daily before bedtime. Administer 5 mg for 4-6 weeks, and after evaluating the clinical response, it can be increased to 10 mg. When increasing to 10 mg per day, monitor for gastrointestinal adverse reactions carefully. Underweight women over 85 years of age should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience in using this drug in children.

This medication should not be used by individuals with allergies to certain ingredients, pregnant or breastfeeding women, and those with genetic disorders resulting in lactose intolerance. Individuals with heart disease or heart conduction disorders should be cautious when using this drug, as it may cause bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this drug with caution due to the risk of gastrointestinal bleeding or exacerbation of ulcers. Those with asthma or obstructive pulmonary diseases may experience worsening symptoms due to bronchial contraction and increased mucus production, so caution is advised. Patients with extrapyramidal disorders such as Parkinson's disease may experience worsening symptoms, so careful monitoring is necessary. This medication contains certain coloring agents, and individuals allergic to these components should also use it with caution. It may affect the heart and can lead to serious side effects such as syncope, bradycardia, heart block, myocardial infarction, and heart failure, so if symptoms occur, consult a doctor immediately. Serious adverse reactions such as gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, movement disorders, severe muscle spasms or neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and unexplained sudden death have also been reported, so caution is needed. During the use of this drug, various neuropsychiatric symptoms and adverse reactions involving the cardiovascular, digestive, skin, and musculoskeletal systems may occur, including nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, aggressive behavior, tremors, walking disabilities, involuntary movements, decreased concentration, mental sluggishness, drowsiness, edema, abdominal pain, pain, hives, blood dyscrasia, anemia, dehydration, increased CPK, liver function abnormalities, hepatitis, and jaundice. This medication is not used for other types of memory disturbances unrelated to dementia and must be taken under the diagnosis and supervision of an experienced physician. Patients with heart disease or electrolyte abnormalities may need to undergo an electrocardiogram due to the risk of cardiac arrhythmias when taking this medication. Caution is needed when driving or operating machinery, as symptoms such as dizziness, fatigue, and muscle cramps may occur. This drug is metabolized by specific enzymes, so there may be interactions when taken with other medications; therefore, consult a doctor or pharmacist about concomitant medications. Pregnant or breastfeeding women are advised not to use this medication, and if absolutely necessary, breastfeeding should be discontinued. Safety for pediatric use has not been established, so it should not be used in children. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may arise, requiring immediate emergency treatment. This medication should be stored out of reach of children, and transferring it to another container may degrade its quality, so caution is advised.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in oral or ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, abnormal breathing accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• muscle pain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering and kept at room temperature between 1 and 30 degrees Celsius. Maintaining this storage condition can help preserve the drug's effectiveness for a long time.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle