Entarozatan Plus Tablets

Adult dose

The usual dose of this medication is one tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily. A daily dose exceeding Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg is not advisable. Patients whose blood pressure is not controlled with Losartan or Hydrochlorothiazide monotherapy should start with one tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily.

Child dose

There is no experience with the use of this medication in children and adolescents (under 18 years old), so it should not be administered to these populations.

This medication should not be taken during pregnancy, especially in the second and third trimesters, as it can cause serious harm to the fetus. If pregnancy is confirmed, the medication should be discontinued as soon as possible, and caution is necessary for the health of the fetus and newborn. This medication is contraindicated in certain patients. For example, patients who are allergic to this medication or its components, those with severely impaired renal function, patients with severe liver dysfunction, pregnant women, and those with certain electrolyte abnormalities should not take this drug. Additionally, patients with low blood pressure, problems with renal arteries, a history of liver disease, hyperuricemia or gout, and elderly patients should exercise special caution when administering this medication. Because this drug lowers blood pressure, symptoms of hypotension may occur in patients who have excessively low blood pressure or a decreased blood volume. This medication may cause an electrolyte imbalance in the blood, so regular blood tests should be performed to check the levels of potassium, sodium, etc. Symptoms of hypokalemia or hyperkalemia may occur, so patients should be aware of these symptoms. Dizziness, drowsiness, and other symptoms may occur during use, so care should be taken when driving or operating machinery. These symptoms may be exacerbated at the beginning of treatment or when changing dosages. This medication may interact with other drugs, so consultation with a doctor is necessary, especially when taken in conjunction with potassium-sparing diuretics, potassium supplements, non-steroidal anti-inflammatory drugs, lithium preparations, etc. It is also advisable to avoid grapefruit juice. Adverse reactions reported during the use of this medication include dizziness, headache, cough, abdominal pain, rash, edema, etc., and rarely angioedema or severe skin reactions may occur, so if symptoms are severe or persistent, consult a healthcare provider immediately. The safety and efficacy of this medication have not been established in children and adolescents, so it should not be used in these populations. In cases of overdose, symptoms such as hypotension, dehydration, and electrolyte imbalance may occur, so the prescribed dosage must be followed strictly. If an overdose is suspected, seek medical attention immediately. Store out of reach of children, and keep the medication sealed in its original container, avoiding transfer to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination changes

Mild side effects

• Abdominal pain
• edema/swelling
• palpitations
• back pain
• dizziness
• cough
• sinusitis
• upper respiratory infection
• weakness/fatigue
• diarrhea

This medication is sensitive to light, so it should be stored in a container that protects it from light. Additionally, it should be stored at room temperature between 1 to 30 degrees Celsius to maintain its effectiveness.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle