Diadryn Capsule (Diacerhein)

Adult dose

Adults: Administer 50∼100mg of diacerein daily orally in 1∼2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with certain diseases. Individuals with inflammatory bowel disease or intestinal obstruction syndrome, as well as those experiencing unexplained abdominal pain, should not take this medication. Additionally, people allergic to this medication or its components, and Rhein class drugs should avoid it. Patients with liver disease or a history of liver disease, and children under 15 years old should not take this medication. This medication contains lactose, so individuals with lactose intolerance or specific genetic metabolic disorders should avoid taking it. Caution should be exercised in using this medication in patients with a history of small intestine or colon diseases, pregnant or nursing women, and seniors over 65 years old. In particular, elderly patients may need to take a reduced dose. Taking this medication may cause gastrointestinal symptoms such as diarrhea, abdominal pain, and constipation, and prolonged use may increase the risk of gastrointestinal bleeding, ulcers, or perforation. Rarely, pigmentation of the rectal mucosa may occur. If diarrhea is severe, there is a risk of dehydration or electrolyte imbalance, so care should be taken. Skin rashes, itching, or eczema may also occur, and liver enzyme levels may rise due to liver function abnormalities. When taking this medication for an extended period, it is essential to follow the doctor's instructions, and if diarrhea occurs, the use should be stopped immediately, and medical consultation should be sought. It is advisable to avoid using laxatives in conjunction with diarrhea. Caution is also required regarding liver damage when taken along with other medications that may cause liver toxicity or have existing liver function issues. Alcohol consumption should be limited. Antacids containing calcium, magnesium, or aluminum, or taking it with salt may interfere with the absorption of this medication, so they should be taken with a 2-hour interval. When taken concurrently with diuretics, enhanced diuretic effects may lead to dehydration or hypokalemia, so care should be exercised. The risk of arrhythmia may increase when used in conjunction with cardiac glycosides, so caution is needed. It is preferable for pregnant or nursing women to avoid taking this medication. Animal studies have reported delayed fetal bone formation, and a small amount may be transmitted through breast milk. In cases of overdose, severe diarrhea may occur, in which case appropriate treatment, such as electrolyte supplementation, should be administered.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevated liver enzymes in serum

This medication is sensitive to air and moisture and should be stored in a tightly closed container. The storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature to preserve the drug's efficacy and safety.

Appearance

A hard capsule filled with a brownish-yellow contents, with a white upper and yellow lower part.

Package unit

For domestic use - 30 capsules/bottle, For domestic use - 500 capsules/bottle