Donepezil 5 mg Tablet (Donepezil Hydrochloride Hydrate)

Adult dosage

Administer 5 mg of Donepezil Hydrochloride once a day before bedtime. Initially maintain a dosage of 5 mg for 4-6 weeks, then evaluate clinical response to increase to 10 mg if necessary. When increasing to 10 mg per day, caution should be taken regarding gastrointestinal adverse reactions.

Children's dosage

No experience in pediatric use.

This medication contains Donepezil Hydrochloride Hydrate as its main ingredient and is used for the treatment of symptoms of Alzheimer's-type dementia. This medication should not be used in certain patients. For example, individuals with allergies to this medication, its components, or similar ingredients, pregnant women or those who may become pregnant, and nursing mothers should not take this medication. Additionally, individuals sensitive to lactose, those with genetic conditions such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption, should also not take this medication. Patients with heart disease should use this medication cautiously, as it may cause a slowing of the heart rate or arrhythmias. Those taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should observe caution due to potential gastrointestinal issues. Patients with a history of asthma or chronic obstructive pulmonary disease may experience bronchoconstriction or increased mucus secretion, leading to worsened symptoms when taking this medication. Patients with extrapyramidal disorders such as Parkinson's disease may experience worsening of symptoms. This medication contains a dye called Yellow No. 5, so caution should be exercised by those who are allergic to this component. During treatment with this medication, a variety of adverse reactions may occur. For example, heart-related issues (bradycardia, heart block, myocardial infarction), gastrointestinal issues (peptic ulcers, gastrointestinal bleeding), liver function abnormalities, seizures, movement disorders, muscle issues, difficulty breathing, acute pancreatitis, acute renal failure, and sudden death have been reported. Additionally, symptoms such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, aggressive behavior, depression, confusion, palpitations, rashes, myalgia, and others may also occur. This medication may affect the heart, so patients with a history of heart disease or QT interval prolongation should undergo an ECG to monitor their condition. It may influence the gastrointestinal system, increasing gastric acid secretion, so those with a history of peptic ulcers should observe whether symptoms worsen. This medication may affect the ability to drive or operate machinery; therefore, caution is advised when starting treatment or changing the dosage. Pregnant or nursing women are advised not to use this medication unless absolutely necessary and after consulting a professional. This medication may interact with various drugs; thus, individuals taking other medications should consult their physician or pharmacist. In case of overdose, symptoms may include nausea, vomiting, bradycardia, hypotension, respiratory depression, seizures, and immediate medical attention is required.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, pain in mucous membranes of mouth/eyes, difficulty or shortness of breath, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion of consciousness, vision abnormalities, paralysis, urination.

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• myalgia

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is advisable to keep it at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's efficacy and prevent degradation.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle