Rimadrene Tablets (Rimiprost Alpha-Dex)

Adult dosage

1. For improvement of ischemic symptoms such as ulcers, pain, and coldness due to thromboangiitis obliterans (Buerger's disease), the usual adult dose is 2 tablets orally 3 times daily. 2. For improvement of subjective symptoms (lower-limb pain and numbness) and walking ability due to acquired lumbar spinal canal stenosis (in patients with normal SLR test results and bilateral intermittent claudication), the usual adult dose is 1 tablet orally 3 times daily. The dose may be adjusted as appropriate according to age and symptoms.

This drug should not be used in women who are pregnant or may become pregnant. This drug contains lactose, so individuals with genetic conditions that prevent lactose breakdown should not take it. Patients with a tendency to bleed or those taking antiplatelet drugs, thrombolytic agents, or anticoagulants should use caution when using this drug. As hypersensitivity reactions such as skin rash or itching may occur while taking this medication, use should be discontinued immediately if such symptoms arise. Rarely, bleeding may occur, so if bleeding symptoms appear, discontinue the medication immediately and consult a healthcare professional. Gastrointestinal symptoms may include diarrhea, nausea, abdominal discomfort, abdominal pain, decreased appetite, and heartburn. Liver function abnormalities may appear, so it is necessary to regularly check if liver enzyme levels are rising. Symptoms such as rapid heartbeat or low blood pressure, and discoloration of the hands and feet may rarely occur. Headache, flushing, dizziness, warmth, fatigue, swelling, trembling, increased body hair on the legs, and anemia may occur. For patients with lumbar spinal stenosis, symptoms should be closely monitored to decide whether to continue treatment. The effectiveness of this medication is not certain for patients with severe spinal stenosis requiring surgery. Safety during pregnancy has not been confirmed, and uterine contraction activity has been reported in animal studies, so it should not be taken during pregnancy. Safety has not been confirmed in children, and there is no experience using it in pediatric patients. Elderly patients may require caution as body functions may decline, and dosage should be reduced accordingly. Healthy adults should be cautious as administering large amounts may temporarily lower blood pressure.

• Rash
• itching
• bleeding
• diarrhea
• nausea
• abdominal discomfort
• abdominal pain
• loss of appetite
• heartburn
• vomiting

This medication must be stored in a tightly closed container to prevent air and moisture from entering. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius to ensure the medication's efficacy and safety.

Appearance

White round tablet

Package unit

84 tablets/box [21 tablets/blister x 4]