Medication info
Azilasaseong 1mg (Rasagiline Mesylate)

Azilasaseong 1mg (Rasagiline Mesylate)

Prescription medicationTabletOral
Ingredient · strength
Rasagiline Mesylate›1.56mg / 1 tablet
Manufacturer / importer
Daewoong Bio Co., Ltd.
Appearance
White round tablets
Packaging
Domestic-use - 30 tablets per bottle
Approval status
Active

MFDS item code 201907988 · Approved 2019.11.19 · Insurance code 694002710

Summary

Main use
Treatment of idiopathic Parkinson's disease
Who takes it
Adults
Adult dose
This medicine is administered orally once daily to adults as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1 mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended initial dose for patients taking levodopa is 0.5 mg once daily. If well tolerated but an adequate clinical response is not achieved, the dose may be increased to 1 mg once daily. This medicine may be taken with or without food.

Ingredients

Manufacturer
Daewoong Bio Co., Ltd.

Efficacy & effects

Treatment of idiopathic Parkinson's disease

  • Idiopathic Parkinson's disease
  • motor fluctuation symptoms
View approved original text

This medication is used to treat idiopathic Parkinson's disease. In the initial stage, it can be used as monotherapy or as an adjunct therapy with dopamine agonists. Additionally, it is used as an adjunct therapy with levodopa for patients exhibiting motor fluctuations. This medication helps to effectively improve the symptoms of Parkinson's disease.

How to take

Adult dose

This medicine is administered orally once daily to adults as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1 mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended initial dose for patients taking levodopa is 0.5 mg once daily. If well tolerated but an adequate clinical response is not achieved, the dose may be increased to 1 mg once daily. This medicine may be taken with or without food.

Precautions

This medication should not be taken by certain patients. Those who are allergic to the active ingredient or other components of this medication should not take it. Additionally, if patients are taking other MAO inhibitors or have stopped using them less than 2 weeks ago, they should not use this medication. Caution is needed when this medication is used with drugs such as petidine, tramadol, and dextromethorphan as it can pose risks. It should not be administered to patients with moderate to severe liver impairment. This medication may cause a variety of side effects. Commonly reported side effects include headache, dizziness, dermatitis, rhinitis, and musculoskeletal pain, and gastrointestinal symptoms such as nausea, vomiting, constipation, and insomnia may occasionally occur. Mentally, symptoms like depression, hallucinations, and confusion may arise, so caution is advised. Additionally, blood pressure may rise or fall suddenly while taking this medication, so it is recommended to periodically check blood pressure status. Due to the risk of interactions with other drugs, it is imperative to consult a physician or pharmacist. Particularly, combining with other MAO inhibitors, antidepressants, sympathomimetics, and certain pain relievers can lead to serious side effects. Using this medication with some cold medications or decongestants is also not recommended. Smokers should be aware that the effectiveness of this medication may be reduced. Pregnant or breastfeeding women should be cautious when using this medication, as it may pass into breast milk and affect breastfeeding. The safety for children and adolescents under 18 has not been confirmed; therefore, it is advisable not to use it in this population. For elderly patients over 65, special dosage adjustments are not necessary, but caution regarding the potential for side effects should be exercised. In case of overdose, serious symptoms such as hypomania, hypertensive crisis, and serotonin syndrome may appear, and immediate medical attention is required. There is no specific antidote for this medication, so symptomatic treatment according to symptoms is necessary. This medication should be stored out of reach of children, and it must be kept in a tightly sealed container to prevent exposure to air and moisture. Ideal storage temperature is in a cool place between 1-25 degrees Celsius.

Side effects

  • Influenza
  • skin cancer
  • leukopenia
  • allergy
  • decreased appetite
  • depression
  • hallucinations
  • headache
  • cerebrovascular accident
  • conjunctivitis
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  • dizziness
  • angina
  • myocardial infarction
  • rhinitis
  • abdominal distension
  • dermatitis
  • vesicular rash
  • musculoskeletal pain
  • neck pain
  • arthritis
  • urgency
  • fever
  • malaise
  • peripheral edema
  • falls
  • joint pain
  • low back pain
  • cough
  • insomnia
  • upper respiratory infection
  • orthostatic hypotension
  • nausea
  • constipation
  • vomiting
  • dry mouth
  • diarrhea
  • abdominal pain
  • dyspepsia
  • hernia
  • infection
  • gingivitis
  • traumatic injury
  • weight loss
  • tendinitis
  • movement disorder
  • drowsiness
  • sensory disturbance
  • ataxia
  • muscle rigidity
  • myasthenia
  • anorexia
  • abnormal dreams
  • respiratory distress
  • rash
  • hyperhidrosis
  • petechiae
  • melanoma
  • confusion
  • carpal tunnel syndrome
  • balance disorder
  • hypertension
  • pathological gambling
  • increased libido
  • hypersexuality
  • compulsive spending or buying
  • binge eating
  • compulsive eating
  • hypotension
  • excessive drowsiness
  • acute renal failure
  • malignant hyperthermia
  • spinal fractures
  • rib fractures
  • tendon injury
  • pelvic fractures
  • leg fractures
  • upper limb fractures
  • low back pain
  • knee arthroplasty
  • herniated disc
  • hypoglycemia
  • weight loss
  • dysuria
  • hematuria
  • frequency of urination
  • vaginitis
  • conjunctival hyperemia
  • diplopia
  • visual impairment
  • skin thickening
  • palpitations
  • arrhythmia
  • gastrointestinal discomfort
  • gastroesophageal reflux
  • excessive salivation
  • irritable bowel syndrome
  • fissured tongue
  • increased bowel movements
  • nonspecific intestinal disease
  • esophagitis
  • excess gastric acid
  • gastroesophageal reflux disease
  • gastric irritation
  • gastritis
  • intestinal motility disorder
  • periodontitis
  • Helicobacter pylori gastritis
  • anemia
  • leg pain
  • chest pain
  • syncope
  • periorbital edema
  • facial flushing
  • pain
  • pulmonary tuberculosis
  • hallucination
  • sleep disorder
  • aggression
  • amnesia
  • memory impairment
  • lethargy
  • sleep talking
  • psychosexual disorder
  • skin numbness
  • tremor
  • freezing phenomenon
  • limb shaking
  • myoclonic jerks
  • leg cramps
  • polyuria
  • tremors
  • stuttering
  • speech disorder
  • vocal cord paralysis
  • language disorder
  • localized inflammation
  • itching
  • urticaria
  • abscess
  • hair loss
  • subdural hematoma
  • contusion
  • abnormal phlegm
  • increased phlegm
  • cold
  • bronchitis
  • pneumonia
  • heartburn
  • systemic weakness
  • fatigue
  • exacerbated tremor
  • neck pain

Not everyone experiences these, and they can vary from person to person.

Storage

This medication must be stored in a tightly sealed container to prevent air and moisture from entering. A cool storage temperature between 1 and 25 degrees Celsius is suitable.

Appearance and packaging

Appearance

White round tablets

Package unit

Domestic-use - 30 tablets per bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.