Adopen 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Adults: Administer 5 mg once daily before bedtime as Donepezil Hydrochloride. Donepezil concentration reaches a steady state after 15 days of administration, and the frequency of adverse reactions may be influenced by the dosage increase rate; therefore, maintain the 5 mg dose for 4-6 weeks. After evaluating clinical responses during this period, the dosage may be increased to 10 mg. When increasing to a daily dose of 10 mg, attention should be paid to gastrointestinal adverse reactions.

Child dose

Children: There is no experience of use in children.

This medication should not be used by patients with allergies to specific components. Pregnant or breastfeeding women should also avoid taking this medication for safety. Patients who are genetically lactose intolerant should be careful and avoid taking this medication. Patients with heart disease or problems with heart rhythm should use this medication cautiously, as bradycardia or arrhythmias may occur. Care is needed for patients with a history of peptic ulcer or those taking anti-inflammatory analgesics due to the risk of gastrointestinal bleeding or worsening ulcers. Patients with asthma or obstructive pulmonary disease should be cautious as bronchoconstriction or increased mucus production may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should take this medication carefully as it may exacerbate symptoms. Rarely, serious side effects such as heart issues, gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, muscle abnormalities, acute pancreatitis, acute renal failure, and sudden death may occur. Additionally, various side effects such as dizziness, nausea, vomiting, diarrhea, headache, insomnia, hallucinations, anxiety, and depression have been reported; if any unusual symptoms occur while taking this medication, consult a doctor immediately. This medication is used in the treatment of dementia, and its therapeutic effects should be periodically evaluated; if no effect is observed, consideration should be given to discontinuation. Care is necessary when driving or operating machinery, especially when first taking or increasing dosage, as dizziness or fatigue may occur. This medication may interact with other drugs, especially when taken with heart-related medications, antibiotics, antidepressants, antipsychotics, anti-inflammatory analgesics, etc., so consulting a specialist is advised. Pregnant or breastfeeding women are advised to avoid this medication, and if it must be taken, discontinuing breastfeeding is safer. Safety for children has not been established, so it is generally not recommended for use in children. In case of overdose, there is a risk of nausea, vomiting, bradycardia, hypotension, convulsions, and respiratory distress; immediate medical treatment is needed and antidotes such as atropine may be used. This medication should be stored out of the reach of children, and it is important not to transfer it to another container to maintain quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, abnormal respiratory symptoms accompanied by cough and fever, yellowing of the skin or eyes (jaundice), severe overall malaise, sudden and very severe headache, thunderclap headache, seizures, consciousness confusion, vision changes, paralysis, urination

Mild side effects

• Loss of appetite
• nausea
• vomiting
• diarrhea
• insomnia
• drowsiness
• dizziness
• headache
• fatigue
• fever

This medication should be stored in a tightly sealed container to prevent air from entering, and it is recommended to store it at a temperature between 1°C and 30°C at room temperature. This will help maintain the efficacy of the medication and prevent degradation.

Appearance

Yellow, round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle