Mefoglipitin Duo Tablet 2.5/500 mg

Adult dose

The dosage of this medication is determined by considering each patient's treatment regimen, efficacy, and tolerability, with a maximum recommended dosage of 2.5 mg of linagliptin and 1000 mg of metformin not exceeding 2 times a day. This drug is administered 2 times a day with meals. 1. Patients not using metformin: The initial dose is 1 tablet of this medication 2.5/500 mg taken twice daily, and can be increased to 1 tablet of 2.5/1000 mg twice daily. 2.

This medication may cause a serious side effect known as lactic acidosis, and should not be administered to certain patients. In particular, it should not be used in patients with allergies to its ingredients or those with Type 1 diabetes, lactic acidosis, diabetic ketoacidosis, diabetic pre-coma, or severe renal impairment. It is also advisable for patients with acute conditions that may affect kidney function, such as dehydration, severe infections, acute myocardial infarction, and shock, to avoid this medication. Women who are pregnant or breastfeeding should also avoid taking this medication. Care should be taken for the possibility of hypoglycemia when using this drug, especially in combination with medications that have a risk of hypoglycemia such as sulfonylureas or insulin. Lactic acidosis, although rare, is a very serious side effect, and if symptoms such as abdominal pain, muscle cramps, or weakness appear, immediate medical attention should be sought. Patients with impaired kidney function should regularly undergo kidney function tests before taking this medication, and it should not be used in cases of severely impaired kidney function. Patients with poor heart function should be cautious when using this medication, and it should be temporarily discontinued during acute surgeries or administration of radiocontrast media containing iodine. This medication can reduce vitamin B12 levels, so regular checks for vitamin B12 deficiency are needed during long-term use. Additionally, this medication may interact with several other medications, so if any other medications are currently being taken, it is essential to inform healthcare professionals and monitor carefully. Women who are pregnant or planning to become pregnant are advised to use insulin therapy instead of this medication, and the medication should also be avoided during breastfeeding. Safety and efficacy have not been established in children and adolescents, and it is not recommended for them. The elderly are at a higher risk of reduced kidney function, so dose adjustments and monitoring of kidney function are necessary. Overdose may lead to lactic acidosis, so strict adherence to dosage is required, and if any unusual symptoms occur, immediate medical attention should be sought. When storing, keep in a place out of reach of children, avoid moisture, and do not transfer to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash accompanied by fever, blisters, peeling skin, pain in the mouth/eye mucosa, difficulty breathing or shortness of breath, asthma attacks, breathing difficulties accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, urine

Mild side effects

• Nasopharyngitis
• hypersensitivity
• reduction and deficiency of vitamin B12
• hypoglycemia
• taste disorder
• cough
• reduced appetite
• diarrhea
• constipation
• nausea

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It should be kept at room temperature between 1 to 30 degrees Celsius to maintain its effectiveness.

Appearance

Biconvex oval film-coated tablets of bright yellow color

Package unit

60 tablets/PTP[(10 tablets/PTP × 6)]