Cox-2 Capsule 100 Milligrams (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient and may be taken with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) : Take celecoxib 200 mg once daily, or 100 mg twice daily. 2. Rheumatoid arthritis : Take celecoxib 100 mg or 200 mg twice daily. 3. Ankylosing spondylitis (AS) : Administer celecoxib 200 mg once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased up to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea : The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment : For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be used with caution in individuals who regularly consume more than three alcoholic beverages a day, as it can pose a risk of gastrointestinal bleeding and should be consulted with a doctor or pharmacist. This medication may cause serious cardiovascular issues such as thrombosis, myocardial infarction, or stroke, and should only be used at the lowest effective dose and for the shortest duration necessary. Patients should be closely monitored for cardiovascular symptoms such as chest pain, shortness of breath, weakness, or speech difficulties while taking this medication, and should immediately inform healthcare providers if these symptoms develop. This medication may cause serious gastrointestinal problems such as perforation, ulcers, and bleeding, so any signs of epigastric pain, dyspepsia, black stools, or hematemesis require immediate evaluation and treatment by medical personnel. Particularly in elderly patients or those with a history of gastrointestinal disorders, the risk of gastrointestinal issues is increased and warrants caution. This medication should not be administered to patients with specific allergies or liver, kidney, heart diseases, pregnant or breastfeeding women, and those with certain genetic metabolic disorders. Patients with impaired liver or kidney function, asthma, hypertension, heart failure, or diabetes should use this medication carefully and require thorough monitoring by healthcare providers. Common side effects can include dyspepsia, diarrhea, headache, dizziness, hypertension, cough, itching, rash, and edema; if serious side effects are suspected, immediate consultation with healthcare providers is necessary. This medication can affect liver and kidney function; therefore, regular blood tests and function tests are required. As this medication can interact with other drugs, any other medications being taken must be disclosed to healthcare providers, especially caution is needed when taken with blood pressure medications, anticoagulants, antidepressants, and antibiotics. Women who are pregnant or planning to become pregnant should not take this medication, and breastfeeding mothers should avoid taking it or stop breastfeeding. This medication's safety and efficacy have not been established for use in children and adolescents under 18 years of age and is not recommended for such use. Elderly individuals have an increased risk of side effects due to decreased bodily functions, thus extra caution and possible dosage adjustments are needed when taking this medication. Drowsiness or dizziness may occur while taking this medication, hence driving or operating machinery should be avoided. In the case of overdose, symptoms such as nausea, vomiting, drowsiness, and gastrointestinal bleeding may occur, and immediate medical attention is required. This medication should be stored out of reach of children and should not be transferred to another container.

Gastrointestinal bleeding, cardiovascular thrombotic response, myocardial infarction, stroke, upper and lower gastrointestinal perforations, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, delirium, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, headache, leg cramps, tension increase, sensory impairment, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, malaise, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, vasculitis, thrombophlebitis, deep vein thrombosis, cerebral hemorrhage, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast pain, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased sodium in the blood, increased potassium in the blood, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial sac, joint pain, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendonitis, myositis, fractures, tendon rupture, back pain, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, pericarditis, contact dermatitis, injection site reaction, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reaction, hallucinations, pulmonary embolism, interstitial pneumonia, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, female infertility

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is important to maintain a storage temperature between 15 to 30 degrees Celsius to preserve the medication's effectiveness.

Appearance

Capsule with light blue upper part and white lower part filled with white to light yellow powder

Package unit

200 capsules/bottle, 30 capsules/bottle