Medication info
Rasagiline Tablets 1.0 mg (Rasagiline Mesylate)

Rasagiline Tablets 1.0 mg (Rasagiline Mesylate)

Prescription medicationTabletOral
Ingredient · strength
Rasagiline Mesylate›1.56mg / 1 tablet
Manufacturer / importer
Jeil Pharmaceutical Co., Ltd.
Appearance
White round tablet
Packaging
30 tablets/bottle
Approval status
Active

MFDS item code 201907622 · Approved 2019.10.31 · Insurance code 645405650

Summary

Main use
Treatment of idiopathic Parkinson's disease
Who takes it
Adults
Adult dose
This medicine is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy with a dopamine agonist: Administer 1mg orally once daily. 2) Adjunctive therapy with levodopa: The recommended initial dose for patients taking levodopa is 0.5mg once daily. If well tolerated and the clinical response is insufficient, the dose may be increased to 1mg once daily. This medicine may be taken with or without food.

Ingredients

Manufacturer
Jeil Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of idiopathic Parkinson's disease

  • Idiopathic Parkinson's disease
  • motor fluctuations
View approved original text

This medication is used for the treatment of patients with idiopathic Parkinson's disease. In the early stages, it can be used as monotherapy or as an adjunct to dopamine agonists. Additionally, it helps patients with motor fluctuations known as 'end of dose fluctuations' as an adjunct to levodopa. This medication is used to effectively manage and improve the symptoms of Parkinson's disease.

How to take

Adult dose

This medicine is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy with a dopamine agonist: Administer 1mg orally once daily. 2) Adjunctive therapy with levodopa: The recommended initial dose for patients taking levodopa is 0.5mg once daily. If well tolerated and the clinical response is insufficient, the dose may be increased to 1mg once daily. This medicine may be taken with or without food.

Precautions

This medication should not be administered to certain patients. Individuals allergic to any of the ingredients should not take it. It should not be used if currently taking or has discontinued other MAO inhibitors within the last 2 weeks. It should also be avoided in patients currently taking or who have stopped taking the analgesic pethidine within the last 2 weeks. Patients taking tramadol or dextromethorphan should avoid using this medication as well. Patients with moderate to severe liver impairment should not take this medication. While taking this medication, various side effects may occur. Commonly reported side effects include headaches, dizziness, nausea, insomnia, and musculoskeletal pain. Symptoms such as depression, hallucinations, dermatitis, rhinitis, fever, and fatigue may also occur. Rarely, myocardial infarction, cerebrovascular accidents, and cardiac-related abnormal symptoms have been reported. This medication is used for the treatment of Parkinson's disease and may cause movement disorders or dopamine-related side effects. Particularly, when taken with other dopaminergic drugs, low blood pressure or sedation may worsen, therefore caution is advised. Drowsiness or sudden sleep may occur while driving or operating machinery, so care should be taken. This medication has many drug interactions, so it is essential to consult with a healthcare professional when taken together with other MAO inhibitors, antidepressants, analgesics, cold medications, or CYP1A2 inhibitors. Smokers need to be aware that the effectiveness of this medication may be reduced. Pregnant women should exercise caution when taking this medication, and those who are nursing should also be cautious as the drug may be transferred through breast milk. The safety and efficacy in children under 18 years old have not been established, so it is advisable not to use it in this age group. Older adults aged 65 years and above can take it without special dosage adjustment. In case of overdose, symptoms such as severe hypertension, serotonin syndrome, or mild mania may occur, and immediate medical attention should be sought for appropriate treatment. This medication should be stored between 1°C and 25°C, in a secure place out of reach of children. Transferring it to another container can cause degradation of quality or accidents, so it must be avoided.

Side effects

  • influenza
  • skin cancer
  • leukopenia
  • allergy
  • appetite loss
  • depression
  • hallucinations
  • headache
  • cerebrovascular accident
  • conjunctivitis
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  • dizziness
  • angina
  • myocardial infarction
  • rhinitis
  • abdominal distension
  • dermatitis
  • vesicular rash
  • musculoskeletal pain
  • neck pain
  • arthritis
  • urgency
  • fever
  • fatigue
  • nausea
  • peripheral edema
  • fall
  • arthralgia
  • low back pain
  • cough
  • insomnia
  • upper respiratory infection
  • orthostatic hypotension
  • constipation
  • vomiting
  • dry mouth
  • diarrhea
  • abdominal pain
  • dyspepsia
  • hernia
  • infection
  • gingivitis
  • accidental injury
  • weight loss
  • tendinitis
  • movement disorders
  • drowsiness
  • sensory abnormalities
  • ataxia
  • muscle hypertonia
  • myasthenia
  • poor appetite
  • abnormal dreams
  • respiratory distress
  • rash
  • hyperhidrosis
  • petechiae
  • melanoma
  • confusion
  • carpal tunnel syndrome
  • balance disorder
  • hallucinations
  • hypertension
  • pathological gambling
  • increased libido
  • hypersexuality
  • compulsive spending or buying
  • binge eating
  • compulsive eating
  • hypotension
  • excessive drowsiness
  • acute renal failure
  • malignant hyperthermia
  • spinal fracture
  • rib fracture
  • tendon injury
  • pelvic fracture
  • leg fracture
  • upper limb fracture
  • back pain
  • knee joint replacement
  • intervertebral disc herniation
  • hypoglycemia
  • weight loss
  • dysuria
  • orthostatic hypotension
  • malignant hyperthermia
  • generalized weakness
  • pulmonary tuberculosis
  • hallucinations
  • semicoma
  • gait disorder
  • ocular movement seizures
  • facial paralysis
  • spinal canal stenosis
  • exacerbation of Parkinson's disease
  • subdural hemorrhage
  • pneumonia
  • myalgia
  • osteoporosis
  • limb weakness
  • concussion
  • unspecified abrasion
  • laceration
  • scoliosis
  • thirst
  • hematuria
  • frequency of urination
  • nocturia
  • urinary incontinence
  • vaginitis
  • conjunctival hyperemia
  • diplopia
  • visual impairment
  • skin thickening
  • palpitations
  • arrhythmia
  • gastrointestinal discomfort
  • gas reflux
  • excessive salivation
  • irritable bowel syndrome
  • fissured tongue
  • increased bowel movements
  • esophagitis
  • hypersecretion of gastric acid
  • gastroesophageal reflux
  • gastric irritation
  • gastritis
  • intestinal motility disorders
  • periodontitis
  • Helicobacter pylori gastritis
  • anemia
  • leg pain
  • chest pain
  • syncope
  • periorbital edema
  • facial flushing
  • pain
  • hallucinations
  • sleep disorders
  • aggression
  • amnesia
  • memory impairment
  • lethargy
  • sleepwalking
  • psychogenic sexual dysfunction
  • skin tingling
  • tremor
  • freezing phenomenon
  • limb shaking
  • systemic muscle cramps
  • leg cramps
  • polyuria
  • tremor
  • stuttering
  • voice disorder
  • vocal cord paralysis
  • language disorder
  • localized inflammation
  • itching
  • urticaria
  • abscess
  • hair loss
  • contusion
  • abnormal sputum
  • increased sputum
  • cold
  • bronchitis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to avoid exposure to air, and it is best stored in a cool place between 1°C and 25°C. This storage will help maintain the medication's effectiveness for a longer duration.

Appearance and packaging

Appearance

White round tablet

Package unit

30 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.