Samsung Linagliptin Duo Tablet 2.5/850 mg

Adult dose

This medication should be taken twice a day with meals. 1. If not currently being treated with metformin: Start with 2.5/500 mg, 1 tablet twice daily and can be increased to 2.5/1000 mg, 1 tablet twice daily. 2. If adequate blood sugar control is not achieved with metformin monotherapy: Administer 2.5 mg of linagliptin twice daily and the current prescribed dose of metformin.

This medication has been reported to cause rare but serious side effects, such as lactic acidosis. Lactic acidosis is a condition where excessive lactate builds up in the body, causing increased acidity, which can be life-threatening without proper treatment. This medication should not be used in certain patients. For instance, it should not be used in patients who have allergies to its ingredients or in those with type 1 diabetes, lactic acidosis, diabetic ketoacidosis, diabetic coma, severe renal impairment, acute infections or dehydration affecting renal function, patients with severely impaired liver function, individuals with acute alcohol intoxication or alcohol dependence, patients with very poor nutritional status, acute heart failure patients, pregnant or nursing women, and patients with a history of myocardial infarction. When administering this medication, care must be taken to avoid the risk of hypoglycemia. Particularly when using this medication with sulfonylureas or insulin, hypoglycemic symptoms may occur, so dosage adjustments of other medications may be necessary. To reduce the risk of lactic acidosis, blood sugar control should be carefully managed, avoid prolonged fasting or excessive alcohol consumption, and exercise extra caution when liver or heart function is impaired. If symptoms like abdominal pain, muscle pain, weakness, or respiratory distress occur, immediate consultation with a doctor is required. Renal function is critical for the excretion of this medication, thus regular kidney function tests must be conducted before and during treatment, and the medication should be discontinued if renal function falls below a certain standard. Patients with diminished cardiac function should be closely monitored when using this medication, and it should be temporarily discontinued prior to examinations involving radiographic iodine contrast agents. Patients undergoing surgery should also stop taking this medication for a period before and after the procedure. This medication can cause rare skin conditions such as acute pancreatitis or bullous pemphigoid, so if severe abdominal pain or blisters appear on the skin, medical personnel should be notified immediately. Long-term use may lead to vitamin B12 deficiency, so if anemia or neurological symptoms develop, vitamin B12 levels should be checked, and supplementation, if necessary, should be administered. This medication can interact with other drugs, so if any other medications are being taken, it is essential to inform a doctor or pharmacist. Special care should be taken when using it with medications that may affect renal function or blood-sugar-lowering medications. Women who are pregnant or planning to become pregnant should avoid this medication, and nursing mothers should also refrain from using it. The safety and efficacy in children and adolescents have not been established; therefore, use in this age group is not recommended. Elderly patients may frequently have declining renal function, so renal function should be regularly monitored and the dosage adjusted accordingly when using this medication. There have been no studies conducted on the effects on driving or operating machinery, so caution is advisable while taking this medication. In the case of overdose, there is a risk of lactic acidosis, and one should seek immediate hospital treatment as hemodialysis is an effective treatment method. This medication should be stored out of reach of children, in a dry place, and it is advisable not to transfer it to other containers.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• severe allergic reactions
• acute pancreatitis
• angioedema
• angioedema
• severe myasthenia gravis

Mild side effects

• Nasopharyngitis
• hypersensitivity
• hypoglycemia
• dysgeusia
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication is sensitive to air and humidity, thus it must be stored in a tightly sealed container. A storage location maintaining room temperature between 1°C and 30°C is suitable.

Appearance

Bright orange oval film-coated tablet

Package unit

60 tablets/PTP[(10 tablets/PTP x 6)]