Adopel 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. If unusual dreams, nightmares, or sleep disturbances occur, consideration may be given to morning dosing of this drug. The concentration of donepezil reaches a steady state 15 days after administration, and the frequency of adverse reactions may be influenced by the rate of dose increase. Therefore, it is recommended to administer 5 mg for 4 to 6 weeks. During this period, clinical responses should be evaluated.

Child dose

There is no experience with use in children.

This medication should not be used by women who are allergic to certain components, pregnant, or breastfeeding, and by patients with genetic lactose intolerance. Patients with cardiovascular diseases or abnormalities in heart rhythm need to use this drug cautiously, as it can slow heart rate or induce arrhythmias. Patients with a history of peptic ulcers or those taking anti-inflammatory analgesics should be careful, as gastrointestinal bleeding or worsening of ulcers may occur. Patients with a history of asthma or obstructive pulmonary diseases must be cautious, as this drug may cause bronchoconstriction and increase mucus secretion, potentially worsening their symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should use this drug cautiously, as it may exacerbate their symptoms. This drug contains certain dyes, so patients allergic to these components should take care. During administration, serious side effects such as fainting, heart issues, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, respiratory distress, acute pancreatitis, and acute renal failure may occur, so immediate consultation with medical personnel should be sought if any abnormal symptoms arise. Although this drug is used to improve cognitive function, consideration should be given to discontinuation if there is no therapeutic effect, and regular evaluations are necessary. Patients with heart disease may require an electrocardiogram, and dizziness or fatigue may occur while taking the medication, so caution is advised when driving or operating machinery. Pregnant or breastfeeding women are advised not to use this medication, and if necessary, consultation with a specialist should be performed before use. This medication can interact with various drugs, so if other medications are being taken, it is essential to inform medical personnel. In case of overdose, symptoms such as nausea, vomiting, bradycardia, respiratory depression, and seizures may occur, and appropriate antidotes and treatments are necessary in emergency situations. Keep out of reach of children and do not transfer to other containers for safety.

Serious side effects

• Fainting
• bradycardia
• heart block
• QT prolongation
• myocardial infarction
• heart failure
• peptic ulcers
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• muscle pain

This medication should be stored in a sealed container to prevent air exposure, ideally at room temperature between 1°C and 30°C. This will help maintain the drug's efficacy and prevent deterioration.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle