Medication info
Gilect 1 mg (Rasagiline Mesylate)

Gilect 1 mg (Rasagiline Mesylate)

Prescription medicationTabletOral
Ingredient · strength
Rasagiline Mesylate›1.56mg / 1 tablet
Manufacturer / importer
Samil Pharmaceutical Co., Ltd.
Appearance
Round white or nearly white tablets
Packaging
PTP - 30 tablets/box [(10 tablets/PTP X 3)]
Approval status
Active

MFDS item code 201907387 · Approved 2019.10.22 · Insurance code 643903740

Summary

Main use
Treatment of idiopathic Parkinson's disease
Who takes it
Adults
Adult dose
This medicine is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended starting dose for patients taking levodopa is 0.5mg once daily. If well tolerated but an adequate clinical response is not achieved, the dose may be increased to 1mg once daily. This medicine may be taken with or without food.

Ingredients

Manufacturer
Samil Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of idiopathic Parkinson's disease

  • Idiopathic Parkinson's disease
  • motor fluctuations
View approved original text

This medication is used to treat the symptoms of idiopathic Parkinson's disease. Initially, it can be used alone or in conjunction with dopamine agonists as an adjunct therapy. Additionally, it is used as an adjunct therapy to complement the effects of levodopa in patients experiencing motor fluctuations known as 'end of dose fluctuations'. This helps alleviate the symptoms of Parkinson's disease and improve the patient's daily life.

How to take

Adult dose

This medicine is administered orally to adults once daily as monotherapy or adjunctive therapy. 1) Monotherapy or adjunctive therapy to a dopamine agonist: Administer 1mg orally once daily. 2) Adjunctive therapy to levodopa: The recommended starting dose for patients taking levodopa is 0.5mg once daily. If well tolerated but an adequate clinical response is not achieved, the dose may be increased to 1mg once daily. This medicine may be taken with or without food.

Precautions

This medication should not be administered to certain patients. It should not be taken if there is an allergy to its active ingredient or other components. Caution is required if the patient is currently taking or has recently stopped taking other MAO inhibitors or certain natural medicines, as it may be dangerous to combine with this drug. In particular, patients taking or having recently discontinued medications such as pethidine, tramadol, or dextromethorphan should not use this drug. This medication should not be given to patients with moderate to severe liver dysfunction. Various adverse effects may occur when taking this medication, including headache, dizziness, dermatitis, nausea, insomnia, and arthralgia, which have been commonly reported. Additionally, mental symptoms such as depression or hallucinations may occur, so changes in symptoms should be closely monitored. This medication can cause side effects such as movement disorders or hypotension, especially when taken with other Parkinson's disease treatments, so more caution is needed. Impulse control disorders may arise, so patients and their caretakers should be aware of compulsive behaviors or pathological gambling tendencies and regularly check the patient's condition. For patients with impaired liver function, blood levels of this drug may increase, so liver function should be assessed before administration and should be used with caution. Drowsiness or sudden sleep may occur during driving or operating machinery, so hazardous activities should be avoided in case such symptoms are present. This drug has a high potential for interactions with other medications, so it is essential to consult with a healthcare professional, especially when combined with other MAO inhibitors, antidepressants, sympathomimetics, or certain analgesics. The safety of this drug has not been established in pregnant or breastfeeding women, so it should be used cautiously. It is advisable not to use it in children under 18, as safety and efficacy have not been confirmed. In the case of overdose, serious side effects can occur, and appropriate treatment should be sought immediately at a medical facility. This medication should be kept out of the reach of children and stored in a tightly sealed container at temperatures between 1 degree and 25 degrees Celsius.

Side effects

  • Influenza
  • skin cancer
  • leukopenia
  • allergy
  • decreased appetite
  • depression
  • hallucinations
  • headache
  • cerebrovascular accident
  • conjunctivitis
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  • dizziness
  • angina pectoris
  • myocardial infarction
  • rhinitis
  • abdominal distension
  • dermatitis
  • vesicular rash
  • musculoskeletal pain
  • neck pain
  • arthritis
  • urinary urgency
  • fever
  • fatigue
  • peripheral edema
  • falling
  • arthralgia
  • low back pain
  • cough
  • insomnia
  • upper respiratory infection
  • orthostatic hypotension
  • nausea
  • constipation
  • vomiting
  • dry mouth
  • diarrhea
  • abdominal pain
  • dyspepsia
  • hernia
  • infection
  • gingivitis
  • accidental injury
  • weight loss
  • tendinitis
  • movement disorder
  • drowsiness
  • sensory disturbance
  • ataxia
  • increased muscle tone
  • myasthenia gravis
  • poor appetite
  • vivid dreams
  • respiratory distress
  • rash
  • hyperhidrosis
  • hemorrhagic spots
  • bleeding
  • melanoma
  • confusion
  • carpal tunnel syndrome
  • balance disorder
  • hypertension
  • pathological gambling
  • increased libido
  • hypersexuality
  • compulsive buying or spending
  • binge eating
  • compulsive eating
  • hypotension
  • excessive drowsiness
  • acute renal failure
  • vertebral fracture
  • rib fracture
  • tendon injury
  • pelvic fracture
  • leg fracture
  • upper limb fracture
  • low back pain
  • knee arthroplasty
  • herniated disc
  • hypoglycemia
  • weight loss
  • urination difficulties
  • orthostatic hypotension
  • malignant hyperthermia
  • generalized weakness
  • pulmonary tuberculosis
  • hallucinations
  • semicoma
  • gait disturbance
  • ocular motor seizures
  • facial paralysis
  • spinal canal stenosis
  • worsening of Parkinson's disease
  • subdural hemorrhage
  • pneumonia
  • myalgia
  • osteoporosis
  • limb weakness
  • concussion
  • unspecified abrasion
  • laceration
  • scoliosis
  • thirst
  • hematuria
  • frequent urination
  • vaginitis
  • conjunctival injection
  • diplopia
  • visual impairment
  • skin thickening
  • palpitations
  • arrhythmia
  • gastrointestinal discomfort
  • gas reflux
  • excessive salivation
  • irritable bowel syndrome
  • fissured tongue
  • increased bowel movements
  • unspecified gastrointestinal disorder
  • esophagitis
  • excessive gastric acid
  • gastroesophageal reflux
  • gastric irritation
  • gastritis
  • bowel motility disorder
  • periodontitis
  • Helicobacter pylori gastritis
  • anemia
  • leg pain
  • chest pain
  • syncope
  • periorbital edema
  • facial flushing
  • pain
  • hallucination
  • sleep disturbance
  • aggression
  • amnesia
  • memory impairment
  • lethargy
  • sleep talking
  • psychosexual disorder
  • skin tingling
  • tremor
  • freezing phenomenon
  • limb shaking
  • myoclonic jerk
  • leg cramps
  • polyuria
  • tremor
  • stuttering
  • vocal disorder
  • vocal cord paralysis
  • speech impairment
  • localized inflammation
  • itching
  • urticaria
  • eyelid skin disorder
  • boil
  • hair loss
  • contusion
  • abnormal sputum
  • increased sputum
  • cold
  • bronchitis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture. The appropriate storage temperature is a cool place between 1 degree and 25 degrees Celsius.

Appearance and packaging

Appearance

Round white or nearly white tablets

Package unit

PTP - 30 tablets/box [(10 tablets/PTP X 3)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.