Nizatide Tablets 150mg (Nizatidine)

Adult dose

1. Treatment of active gastric and duodenal ulcers Adults: Administer 300mg of nizatidine once daily at bedtime, or 150mg orally twice daily, in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if needed. 2. Prevention of duodenal ulcer recurrence Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may be continued for up to 1 year; results with longer-term treatment are not known. 3. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily, in the morning and evening. Treatment may be continued for up to 12 weeks. 4. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily, in the morning and evening, for 2 weeks. 5. Dose adjustment for patients with severe renal impairment Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer: Creatinine clearance 20~50 ml/min: 150mg once daily; < 20 ml/min: 150mg every other day. Maintenance therapy: Creatinine clearance 20~50 ml/min: 150mg every other day; < 20 ml/min: 150mg every 3 days.

This medicine is an H2-receptor antagonist that is used to treat gastric diseases by reducing gastric acid secretion. Patients who have had allergic reactions to similar medications should not use this drug. Patients with a history of drug hypersensitivity or issues with liver or kidney function should use this drug cautiously. In particular, patients with impaired kidney function may have increased drug concentration, necessitating a reduction in dosage or an increase in dosing intervals. This drug contains the dye Yellow No. 5, so patients allergic to this component should also be cautious. If symptoms of hypersensitivity such as skin rash, itching, or difficulty breathing occur during use, it should be discontinued immediately. Blood abnormalities such as anemia, leukopenia, and thrombocytopenia may occur, so report any unusual symptoms to the hospital. Gastrointestinal symptoms such as constipation, diarrhea, dry mouth, and nausea may occur. Rare cases of elevated liver function tests or liver damage symptoms such as hepatitis and jaundice have been reported, so liver health should be monitored. Occasionally, neurological symptoms such as headache, drowsiness, dizziness, and confusion may occur, so caution is needed when driving or operating machinery. Tachycardia may occur, so patients with heart disease should be cautious. In women, breast enlargement may occur rarely, while men have reported sexual dysfunction. Skin changes such as sweating, hives, and rashes can occur, so monitor for skin changes. This drug is primarily excreted by the kidneys, so elderly patients with reduced kidney function should undergo kidney function testing before administration and keep monitoring kidney status during treatment. Pregnant women or those who may become pregnant should only use this drug when the therapeutic benefits outweigh the risks, and nursing mothers should use it only when necessary. Safety in pediatric patients has not been established, so it should be used with caution in children. This drug has relatively few drug interactions, but caution is advised when used with high doses of aspirin, as it may increase serum salicylate levels. In the case of an overdose, symptoms such as vomiting, diarrhea, and increased salivation may occur, and appropriate medical treatment should be provided if needed. This drug may mask symptoms of gastric cancer, so it must be used only after confirming that it's not gastric cancer. If there is no therapeutic effect, it is advisable to switch to another medication, and liver and kidney function, as well as blood test results, should be regularly monitored during treatment.

• Rash
• itching
• bronchial asthma
• laryngeal edema
• symptoms of anaphylaxis
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is important to maintain storage temperatures between 1 and 30 degrees Celsius (room temperature) to preserve the drug's efficacy for a longer period.

Appearance

Light yellow round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle