Hyalron Injection (Sodium Hyaluronate)

Adult dosage

Administer 25 mg of sodium hyaluronate intra-articularly once a week for 5 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or tendon sheath of the biceps). Adjust the frequency of administration based on symptoms. Since this medicine is injected intra-articularly, it should be performed under strict aseptic conditions.

This medicine should not be used in patients who have had hypersensitivity to this medicine or its components. As this medicine is injected directly into a joint, it is advisable not to administer it if there is a skin disease or infection at the injection site. Care should be taken when using it in patients with liver dysfunction or a history of liver disease as abnormal liver function tests may occur. Individuals allergic to avian protein should not receive this medicine as it may cause hypersensitivity reactions. After administration, shock symptoms may appear, so patients should be carefully observed, and if any abnormal symptoms occur, administration should be stopped immediately and appropriate treatment provided. Symptoms such as swelling of the face or around the eyes, rashes, hives, or itching may occur as allergic reactions, so if these symptoms appear, the use of this medication should be stopped and the hospital should be informed. The injection site may experience temporary pain, swelling, redness, heat, pressure, or bruising, and caution is also required in these instances. Systemic side effects such as nausea, vomiting, fever, or headaches may occur rarely. In patients with severely inflamed arthritis, this medicine may worsen inflammation, so it is advisable to administer it after inflammation subsides. After administration, it is necessary to stabilize the injection site and avoid excessive movement. If the medication leaks out of the joint, pain may intensify, so it must be accurately injected into the joint cavity. Patients with rheumatoid arthritis or gout may experience a temporary increase in inflammation, so caution is needed. Within 48 hours post-injection, it is advised to avoid vigorous activities such as jogging or tennis and long-duration weight-bearing activities. The safety of using this medicine in conjunction with other intra-articular injectables has not been established, so it is advisable not to combine them. Pregnant or potentially pregnant women should consider the necessity and risks of using this medicine carefully, as its safety is not confirmed. Breastfeeding mothers are advised to avoid breastfeeding while using this medicine, as it may be transmitted through breast milk. The safety of this medicine in children has not been sufficiently established, so it should only be used cautiously when absolutely necessary. Elderly patients may experience decreased bodily functions, so extra caution is required upon administration. Maintain aseptic conditions during injections to prevent infection, and do not administer more than 5 injections if symptoms do not improve. If there is fluid accumulation in the joint, it is advisable to remove it prior to injection. This medication is not for use in intravenous or ophthalmological applications; caution is needed in selecting the injection needle and method due to its viscosity. There may be medication residue on the ampule, so the ampule should be shaken to collect the injection solution before slowly drawing it into the syringe. When opening the ampule, it should be done cleanly to avoid contamination. Caution is needed as precipitate may form when mixed with certain disinfectants. This medicine is for single use; any remaining solution after opening should be discarded immediately. It is recommended to administer local anesthetics such as lidocaine before injecting this medication.

Serious side effects

• Hives
• swelling (including facial and eyelid)
• shock (severe allergic reaction)

Mild side effects

• Swelling of the face and eyelids
• facial rash
• itching
• pain
• swelling
• reddening
• heat sensation
• severe local pressure sensation
• petechiae
• nausea

This medicine should be stored in a sealed container to protect from exposure to air and it is safest to store it at a temperature between 1 and 30 degrees Celsius. Therefore, it should be stored in a place that avoids extreme heat or cold.

Appearance

A colorless transparent viscous liquid filled in a glass vial sealed with rubber stoppers at both ends (part of a prefilled syringe system)

Package unit

2.5 mL/prefilled syringe [2.5 mL × 10, 50, 100 vials]