Medication info
Unitok Soft Capsule 10 Milligrams (Alitretinoin)

Unitok Soft Capsule 10 Milligrams (Alitretinoin)

Prescription medicationSoft capsuleOral
Ingredient · strength
Alitretinoin›10mg / 1 capsule
Manufacturer / importer
Korea Union Pharmaceutical Co., Ltd.
Appearance
Brownish oval soft capsules containing a uniform yellow to yellowish-green liquid
Packaging
30 capsules/box [10 capsules/PTPX3]
Approval status
Active

MFDS item code 201907197 · Approved 2019.10.14 · Insurance code 665507670

Summary

Main use
Treatment of chronic severe hand eczema in adults that does not respond to potent topical corticosteroids
Who takes it
Adults
Adult dose
Take 10~30mg once daily with or immediately after a meal. It is preferable to take this medicine at the same time each day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: Start with an initial dose of 10mg and, if needed, increase to 30mg depending on tolerability and effect. Periodic monitoring of blood lipid profile and blood glucose may be necessary during treatment with this medicine. Stop treatment as soon as the hands are clear or almost clear. If hand eczema remains severe after the initial 12 weeks of treatment, discontinue treatment. Also discontinue treatment if the treatment goal has not been reached by week 24.

Ingredients

Manufacturer
Korea Union Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of chronic severe hand eczema in adults that does not respond to potent topical corticosteroids

  • Chronic severe hand eczema
View approved original text

This medication is used to treat chronic severe hand eczema in adults that does not respond to at least 4 weeks of potent topical steroid treatment. Hand eczema is a condition that causes severe inflammation and itching of the skin on the hands, and this medication helps alleviate symptoms and improve skin conditions. It can be used safely while monitoring therapeutic effectiveness under the assessment of a specialist. This medication effectively improves severe symptoms of chronic hand eczema.

How to take

Adult dose

Take 10~30mg once daily with or immediately after a meal. It is preferable to take this medicine at the same time each day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: Start with an initial dose of 10mg and, if needed, increase to 30mg depending on tolerability and effect. Periodic monitoring of blood lipid profile and blood glucose may be necessary during treatment with this medicine. Stop treatment as soon as the hands are clear or almost clear. If hand eczema remains severe after the initial 12 weeks of treatment, discontinue treatment. Also discontinue treatment if the treatment goal has not been reached by week 24.

Precautions

This medication must not be used by women who are pregnant or may become pregnant, as it can cause serious birth defects. While taking this medication, effective contraceptive methods must be used at all times, and regular pregnancy tests should be conducted before, during, and after treatment. If triglyceride levels in the blood are very high, serious side effects such as acute pancreatitis may occur, so lipid levels should be monitored periodically, and any abnormalities should be discussed with a doctor. This medication should not be used in patients with severely impaired liver or kidney function, uncontrolled thyroid function, or vitamin A excess. Patients with a history of mental illness or symptoms of depression should closely monitor their mental health status while taking this medication, and report any worsening symptoms to healthcare professionals immediately. Various side effects, including dry skin, headache, flushing, chapped lips, arthralgia, and myalgia may occur, and if symptoms are severe, consultation with a doctor is needed. It is important to avoid excessive sun exposure and use sunscreen to protect the skin. Wearing contact lenses may cause discomfort, so wearing glasses may be advisable if needed. During treatment, vigorous exercise should be avoided, and if severe diarrhea or rectal bleeding occurs, healthcare personnel should be notified immediately. Taking this medication together with other vitamin A preparations or certain antibiotics (such as tetracyclines) may pose risks, so inform your doctor or pharmacist about any medications you are currently taking. This medication should be swallowed with water during or immediately after meals and should not be chewed. It should not be used by children or nursing mothers, and it is strictly contraindicated for women who are pregnant. It is important to consult healthcare professionals immediately if any unusual symptoms arise after taking the medication.

Side effects

  • Headache
  • erythema
  • flushing
  • increased triglycerides
  • increased cholesterol
  • decreased thyroid-stimulating hormone
  • decreased free T4
  • anemia
  • increased iron binding capacity
  • decreased monocytes
Show 62 more
  • increased platelets
  • anaphylactic reaction
  • hypersensitivity reaction
  • depression
  • mood changes
  • suicidal thoughts
  • dizziness
  • benign intracranial hypertension
  • conjunctivitis
  • dry eyes
  • eye irritation
  • blurred vision
  • cataract
  • decreased night vision
  • tinnitus
  • hypertension
  • vasculitis
  • nosebleeds
  • nausea
  • dry mouth
  • vomiting
  • dyspepsia
  • inflammatory bowel disease
  • increased aminotransferases
  • dry skin and lips
  • cheilitis
  • eczema
  • dermatitis
  • hair loss
  • itching
  • rash
  • skin peeling
  • dry eczema
  • nail disorders
  • photosensitivity reaction
  • hair texture abnormality
  • arthralgia
  • myalgia
  • osteomalacia
  • ankylosing spondylitis
  • fatigue
  • peripheral edema
  • hypertriglyceridemia
  • decreased HDL
  • hypercholesterolemia
  • increased serum creatine phosphokinase
  • diabetes mellitus
  • color blindness
  • contact lens intolerance
  • early epiphyseal closure
  • hyperostosis
  • calcification of ligaments and tendons
  • corneal opacification
  • keratitis
  • inflammatory bowel disease
  • skin allergic reactions
  • anaphylactic reaction
  • purpura
  • severe allergic vasculitis
  • erythema multiforme
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light and should be stored in a container that prevents light from entering. Additionally, it is recommended to store the medication at a temperature between 1 to 30 degrees Celsius. This helps to maintain the effectiveness and safety of the medication.

Appearance and packaging

Appearance

Brownish oval soft capsules containing a uniform yellow to yellowish-green liquid

Package unit

30 capsules/box [10 capsules/PTPX3]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.