Loperi Capsule (Loperamide Hydrochloride)

Adult dose

Acute diarrhea: The initial dose is 4 mg of loperamide hydrochloride taken orally, and the maintenance dose is 2 mg for every loose stool. The usual daily dose is 6-8 mg, with a maximum daily dose of 16 mg. Chronic diarrhea: The initial dose is 4 mg of loperamide hydrochloride taken orally, and for every loose stool until diarrhea is resolved, an additional 2 mg is administered. Afterward, the dose should be adjusted to meet individual patient needs.

Child dose

Acute diarrhea: The initial dose is 2 mg of loperamide hydrochloride taken orally, and the maintenance dose is 2 mg for every loose stool. The maximum daily dose is 6 mg. Adjust as appropriate based on age and symptoms.

This medication should not be used in infants under 24 months of age or in children with chronic diarrhea. It should also not be administered to patients with bacterial diarrhea accompanied by blood or high fever, patients with acute ulcerative colitis, and patients with severe gastrointestinal diseases such as intestinal obstruction. Additionally, it should not be used in patients with hypersensitivity to this medication or those with certain genetic lactose metabolism issues. Patients with poor liver function should use this medication with caution, as neurological side effects may occur, and they should be closely monitored. This medication does not treat the underlying cause of diarrhea but alleviates symptoms, so patients should consult a doctor or pharmacist if symptoms do not improve within 48 hours for acute diarrhea or within 10 days for chronic diarrhea. Diarrhea patients may experience fluid and electrolyte loss, so special attention should be given to hydration and electrolyte replenishment, especially in children. Fatigue, dizziness, drowsiness, and other side effects may occur while taking this medication, so caution is advised when driving or operating machinery. Women in early pregnancy should use this medication only when the benefits outweigh the risks, and breastfeeding women are advised against its use as it may pass into breast milk in small amounts. Elderly patients may have diminished physical function, so dose adjustment and caution are necessary. In case of overdose, serious side effects such as central nervous system depression, respiratory depression, and cardiac arrhythmia may occur, so prescribed doses must be adhered to, and immediate medical assistance should be sought if symptoms appear. The use of this medication in tablet or capsule form is not recommended for children under 7 years old. While drug dependence has not been reported with this medication, some animal studies have shown the potential for dependence with excessive doses, requiring caution.

Serious side effects

• Hives
• angioedema
• toxic epidermal necrolysis
• erythema multiforme
• Stevens-Johnson syndrome
• anaphylactic shock
• severe hypersensitivity reactions
• intestinal obstruction
• abdominal distension
• toxic megacolon

Mild side effects

• Dry mouth
• bloating
• abdominal cramps
• acute pain
• nausea
• vomiting
• headache
• dizziness
• drowsiness
• constipation

Drug interactions

This medication should be discussed with a doctor or pharmacist if taken in conjunction with quinidine or ritonavir.

This medication should be stored in a tightly closed container to protect it from air and moisture, at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the effectiveness of the medication for a longer period.

Appearance

Hard capsule containing a white powder with a yellowish upper part and a milky white lower part

Package unit

10 capsules/PTP