Entiglimet Tablets 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day before or with meals. Treatment usually begins with a low dose, and the dosage may be adjusted based on the patient's currently prescribed medications and blood glucose levels. In clinical trials, the initial daily dose was Glymeperide/Metformin Hydrochloride 2mg/500mg, and the dose can be gradually increased up to 8mg/2000mg based on blood glucose monitoring results. Glymeperide monotherapy is usually not beneficial at a dose greater than 4mg per day.

This medication may cause severe lactic acidosis or hypoglycemia, so treatment should be temporarily suspended and a physician should be consulted if there is a rapid decline in kidney function or symptoms of dehydration. Caution is required for patients at risk of cardiovascular diseases, and should not be administered to patients with specific diseases or conditions. During the first week of dosing, there is a higher risk of hypoglycemia, so special caution is necessary in case of irregular meals, alcohol consumption, or reduced kidney function, and immediate treatment is required if symptoms of hypoglycemia occur. This medication may cause various side effects such as gastrointestinal disorders, skin allergies, blood anomalies, and liver dysfunction. Patients should inform healthcare professionals immediately if any abnormal symptoms arise. Blood sugar control status should be checked regularly, and kidney function and blood tests should be conducted periodically to ensure safe usage. There are many drug interactions; thus, the effect of blood sugar control may vary depending on other medications taken, so it is crucial to inform about any medications being taken, and alcohol consumption should be avoided. Women who are pregnant or breastfeeding should not use this medication, and special caution is needed for children and the elderly. In case of overdose, serious side effects such as hypoglycemia or lactic acidosis may occur, so immediate medical attention should be sought, and appropriate treatment is required in emergencies. This medication requires caution during driving or operating machinery, and should be kept out of reach of children.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, lactic acidosis, consciousness disorder due to lactic acidosis, liver abnormalities (liver dysfunction, jaundice), severe allergic reactions (shock, drop in blood pressure, difficulty breathing), severe skin reactions (severe rash, blisters, skin peeling, pain in oral and ocular mucosa), severe hypoglycemia, severe neurological symptoms (severe headache, seizures, confusion, visual disturbances, paralysis), hematological abnormalities (severe

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, indigestion, constipation, abdominal pain), temporary occurrence of gastrointestinal symptoms, spontaneous resolution of gastrointestinal symptoms during treatment, metallic taste, visual impairment, redness, itching, rash, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, decrease in vitamin B12 concentration, increased liver enzymes, liver dysfunction, hepatitis

Store this medication in a tightly closed container that is well-ventilated, and can be safely stored at room temperature between 1°C and 30°C. Storing this way maintains the medication's effectiveness and prevents deterioration.

Appearance

White oblong film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle