Danazen Simvastatin Tablet 20 mg

Adult dose

The recommended initial dosage is 40 mg once daily. For hypercholesterolemia, the general initial dosage is 20 mg once daily, and mild to moderate hypercholesterolemia patients may start with 10 mg. Administer once daily in the evening 5 to 40 mg. Dosage for specific patient populations should be adjusted; for example, when concomitantly taking verapamil, diltiazem, or dronedarone, it should not exceed 10 mg per day.

Child dose

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), administer 10 mg once daily in the evening. The recommended dosage range is 10 to 40 mg per day, with a maximum dosage of 40 mg per day.

This medication may pose a risk of muscle problems, particularly at high doses, leading to serious muscle injury such as myopathy or rhabdomyolysis. It should not be used in patients with certain conditions or those taking specific medications; for example, patients with liver dysfunction or pregnant women, and those taking strong CYP3A4 inhibitors should not take this medication. Due to its potential impact on liver function, patients with liver disease or those who consume large amounts of alcohol should use this medication cautiously. Patients with reduced kidney function are also at higher risk for muscle damage, so caution is necessary. This medication should be administered cautiously in women, the elderly, and patients with hypothyroidism. Side effects such as muscle pain, weakness, abdominal pain, headache, and dyspepsia may occur, and if serious abnormal symptoms appear, consultation with a physician should be obtained immediately. Interactions with other drugs may increase the risk of muscle damage; therefore, if any other medications are being taken, patients must inform their doctor or pharmacist. Pregnant or breastfeeding women should not take this medication, and women who may become pregnant must use contraception while taking it. This medication is not to be used in children under 10 years old or pre-menstrual pediatric patients. Elderly patients may have increased blood concentration levels of this medication, necessitating dosage adjustment and careful monitoring. During treatment, liver function and muscle status should be regularly monitored for abnormalities. In case of overdose, immediate medical attention should be sought, and it should be stored out of reach of children.

Serious side effects

• Hives
• angioedema
• difficulty breathing
• rhabdomyolysis
• acute renal failure
• severe edema
• hepatitis
• liver failure
• cholestatic jaundice
• fulminant hepatic necrosis

Mild side effects

Abdominal pain, weakness, constipation, diarrhea, dyspepsia, bloating, nausea, headache, upper respiratory infection, edema, atrial fibrillation, gastritis, diabetes, myalgia, insomnia, dizziness, bronchitis, rhinitis, eczema, urinary tract infection, muscle cramps, arthralgia, taste disturbance, ocular movement disorder, facial incomplete paralysis, tremor, sensory disturbance, peripheral neuropathy, peripheral nerve paralysis, mental disorders, anxiety, sleep disorders, depression, cognitive impairment, severe muscle weakness or ophthalmoplegia

This medication should be stored in a tightly closed container to prevent air and moisture from entering and kept at a temperature between 1°C and 30°C. Storing it this way will maintain the effectiveness and safety of the medication.

Appearance

Oval film-coated tablet with yellowish-brown color

Package unit

30 tablets/bottle, 300 tablets/bottle