Donepezil Tablets 5 mg (Donepezil Hydrochloride Hydrate)

Adult dosage

As donepezil hydrochloride, administer 5 mg once a day before bedtime. For 4 to 6 weeks, administer the 5 mg dosage, and afterwards, it may be increased to 10 mg based on clinical response. When increasing the dose to 10 mg per day, caution should be exercised to monitor gastrointestinal adverse reactions. Female patients over 85 years old who are underweight should not exceed 5 mg per day.

Children's dosage

There is no experience in using this medication in children.

This medication contains donepezil hydrochloride as its main component and is primarily used for the treatment of Alzheimer's-type dementia symptoms. This medication should not be used by certain patients, particularly those allergic to this drug or similar components, pregnant women or women who may become pregnant, and nursing mothers. Patients with genetic problems such as lactose intolerance should also avoid this medication. Patients with heart disease, a history of peptic ulcers, those taking nonsteroidal anti-inflammatory drugs, patients with a history of asthma or chronic obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease should use this medication with caution. This medication may cause bradycardia or arrhythmias, gastrointestinal bleeding, liver function abnormalities, seizures, and various muscle-related adverse effects, so if any unusual symptoms occur, immediate consultation with a physician is necessary. It is important to regularly monitor the patient's heart condition during treatment, especially since ECG abnormalities such as QT interval prolongation may occur. This medication can interact with other drugs, particularly with drugs that are metabolized in the liver, potentially altering its effects, so it is essential to inform healthcare providers about any other medications being taken. Pregnant or nursing women should avoid this medication as a rule, and if absolutely necessary, they should follow the guidance of a specialist. Safety for pediatric use has not been established, so it is not used in children. Additionally, this medication may affect driving or machine operation abilities, so caution is required during the initial stages of dosing or when adjusting the dose. In the case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate hospital treatment. Finally, this medication should be stored out of the reach of children, and transferring it to another container is not advisable for maintaining quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing or getting air, asthma attacks, respiratory disturbances with cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, lightning headache, seizures, disorientation, visual disturbances, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• fever
• itching

This medication should be stored in a tightly sealed container to prevent air exposure, and it should be kept at room temperature between 1°C and 30°C. Proper storage helps maintain the effectiveness of the medication and prevents deterioration.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle