Ceres Capsule 100 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted according to the patient, and it may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. 3. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks at 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is celecoxib 400 mg; if needed, an additional 200 mg may be administered on the first day of treatment. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic drinks daily, so it is essential to consult a doctor or pharmacist. This medication may increase the risk of cardiovascular thrombotic events such as myocardial infarction and stroke, so it should only be used at the lowest effective dose for the shortest duration necessary, and immediate medical attention should be sought if cardiovascular symptoms occur. This medication can cause serious gastrointestinal adverse reactions such as gastrointestinal perforation, ulcers, and bleeding, so elderly patients or those with a history of gastrointestinal disorders should carefully monitor for gastrointestinal symptoms while taking it. This medication should not be given to patients with certain allergies, severe impairment of liver or kidney function, active peptic ulcer disease, cardiovascular disease, or pregnant women. Patients with reduced liver or kidney function, asthma, hypertension, heart failure, or diabetes should use this medication cautiously, and regular monitoring is necessary during treatment. Headaches, dizziness, dyspepsia, vomiting, skin rash, hypertension, and edema may occur as side effects; if any abnormal symptoms appear, consult healthcare professionals immediately. As this medication is metabolized in the liver, there may be interactions with other drugs, particularly when taken with specific antibiotics, antidepressants, antihypertensives, anticoagulants, etc. Pregnant women or those who may become pregnant should not take this medication, and nursing mothers should also consult with a doctor to determine whether to use it. The safety and efficacy of this medication in children and adolescents under 18 years of age have not been established, so its use is not recommended. Elderly patients may have a higher risk of decreased kidney and liver function, so special observation and caution are necessary while taking this medication. Regular blood tests, liver and kidney function tests, and electrocardiograms should be performed during treatment to check for abnormalities, and the treatment may need to be discontinued depending on symptoms. Dizziness or drowsiness may occur after taking this medication, so it is advisable to avoid driving or operating machinery. In cases of overdose, symptoms such as vomiting, drowsiness, gastrointestinal bleeding, and acute renal failure may occur, necessitating immediate medical attention.

Gastrointestinal bleeding, cardiovascular thrombotic reaction, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, flatulence, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequent urination, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, increased serum sodium, increased serum potassium, elevated BUN, elevated CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, anorexia, elevated LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, osteoarthritis, skeletal abnormalities, myalgia, neck strain, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various areas, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenia, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, skin nodules, headache, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicidal tendencies, loss of smell, loss of taste, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, generalized edema, facial swelling, fatigue, malaise, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, angioedema, insomnia, anorexia, increased appetite, depression, neuroexcitability, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, vasculitis, pulmonary embolism, interstitial pneumonia, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized pustular dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, female infertility, chest pain, lethargy, drowsiness, nausea, vomiting, upper abdominal pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, coma

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. Moreover, it is important to store it in a cool temperature between 15 to 30 degrees Celsius to maintain its effectiveness.

Appearance

White capsules filled with white to light yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle