Kayril Tablet 2 mg (Glimepiride)

Adult dose

Individualized for each patient. Administered orally once daily, swallowed whole with more than 1/2 cup of water. Should be taken before breakfast or right before the first meal, and it is very important not to skip meals after taking the medication. The initial dose is 1 mg once daily, and can be increased by 1 mg at intervals of 1 to 2 weeks. Generally, additional effects are rare when doses are increased to over 4 mg.

This medication should not be used in patients with insulin-dependent diabetes or those in diabetic ketoacidosis, or comatose patients. Additionally, patients with a history of allergic reactions to this medication or sulfonylureas or sulfonamide drugs should avoid administration. There is no experience with this medication in patients with severely impaired liver or kidney function, and transitioning to insulin therapy is recommended in such cases. Women who are pregnant or may become pregnant, as well as breastfeeding mothers, should not take this medication. Caution is also advised in patients with severe infections, pre- or post-surgical patients, or those who have experienced significant trauma, as insulin therapy may be necessary. Patients with gastrointestinal disorders should be cautious as food absorption may be impaired, increasing the risk of hypoglycemia. This medication contains lactose, and patients with lactose intolerance or certain genetic metabolic disorders should not take it. During the first week of starting this medication, there is a higher risk of hypoglycemia, so blood sugar levels should be closely monitored. This is especially pertinent for elderly patients, those who are malnourished or have irregular eating habits, and frequent alcohol consumers who have a greater risk of hypoglycemia. Patients with decreased kidney or liver function may also respond more sensitively to this medication, so dose adjustment may be necessary. Patients with other endocrine disorders or those taking multiple medications should carefully monitor their blood sugar levels. If symptoms of hypoglycemia occur, immediately inform a doctor or pharmacist and take appropriate action as prescribed. Symptoms of hypoglycemia may arise while taking this medication, including headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, decreased consciousness, etc. Hypoglycemia can usually be rapidly corrected by consuming sugar, so it is important to always carry glucose. Additionally, some patients may experience blurred vision, gastrointestinal disorders, liver dysfunction, blood abnormalities, or allergic reactions. If severe allergic reactions or blood abnormalities occur, stop taking the medication immediately and consult healthcare professionals. Regular medication adherence is crucial, and optimal blood sugar control can be achieved by combining dietary and exercise regimens. Patients and families should be adequately informed about the symptoms and risks of hypoglycemia so that they can handle hypoglycemic events appropriately. During treatment, regular monitoring of blood sugar, liver, and kidney function is necessary, and dose or administration method adjustments should be made according to changes in condition. Care should also be taken when driving or operating machinery, considering the possibility of decreased attention due to hypoglycemia. This medication may interact with other medications, so it is important to inform healthcare professionals of all medications being taken. In particular, blood sugar changes may occur when taken with certain antibiotics, analgesics, steroids, or beta-blockers. Alcohol consumption should be avoided as it can destabilize the blood sugar control effect of this medication. Pregnant or breastfeeding women are advised to consider insulin therapy instead, as it may affect the fetus or newborn. Safety and efficacy for children under 18 have not been established, so it is advisable not to use this medication in that population. Elderly patients may have reduced kidney function, so caution in dose adjustment is necessary. Severe hypoglycemia may occur in the event of overdose, and immediate medical attention should be sought for appropriate treatment. This medication should be kept out of reach of children and stored in its original container to maintain quality.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, hypotension, anaphylaxis, angioedema, Stevens-Johnson syndrome, liver dysfunction (cholestatic jaundice), hepatitis, jaundice, severe blood abnormalities, decreased platelet count and thrombocytopenic purpura, shock, severe hypoglycemia (convulsions, loss of consciousness, coma), severe edema or urinary disturbance accompanied by hypertension

Mild side effects

• Symptoms of hypoglycemia: headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or initiative

This medication is sensitive to air and moisture, so it must be stored in a tightly closed container. It is also recommended to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Green oblong tablets

Package unit

30 tablets/bottle, 100 tablets/bottle